多药耐药相关蛋白在胃癌组织中的表达及意义  

Expression of MRP in gastric carcinoma and significance

作　　者：尹清云[1] 王燕[1] 罗湘江[1] 

机构地区：[1]宁夏医学院附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2004年第12期750-751,共2页Ningxia Medical Journal

摘　　要：目的　探讨胃癌组织中多药耐药相关蛋白 (MRP)的表达与预后以及预测辅助化疗疗效的关系。方法　采用S -P免疫组化法检测 6 4例胃癌组织和 34例癌旁组织中MRP的表达水平。分析 4 5例术后化疗疗效与MRP表达的关系。结果　MRP在胃癌组织中表达阳性率 34.4 % ,与癌旁组织相比有显著性差异 (P <0 .0 5 ) ;胃癌组织中MRP阳性表达与患者的性别、年龄、肿瘤部位及大小、淋巴结转移及浸润深度、病理分化程度和临床分期无显著相关性 (P >0 .0 5 ) ,MRP表达阳性与 5年生存率无显著性差异 (P >0 .0 5 ) ;在行术后辅助化疗的患者中 ,MRP表达阳性与生存率间无显著性差异 (P >0 .0 5 )。结论　MRP在胃癌组织中呈异常高表达 ,与癌旁组织有显著性差别。提示胃癌中存在MRP介导的原发性耐药。Objective To explore the expression of MRP in gastric carcinoma and the relationship between above parameters and the prognosis and predictive value in adjuvant chemotherapy of gastric carcinoma.Methods The expression of MRP were detected in 64 cases gastric carcinoma samples, 34 cases adjacent tissue to cancer as control by S-P immunohistochemical method. The relationship was analyzed between the expression of MRP and curative effect of adjuvant chemotherapy.Results The expression positive rate of MRP in 64 cases with gastric carcinoma was 34.4%, compared with the adjavent tissue to cancer in 34 cases, there was significant difference(P<0.05);There was no significant difference between the positive expression of MRP and patients' sex ,age, tumor location, tumor size, lymth node metastasis,depth infiltration ,histological differentiation and clinical stage (P>0.05); while there was no significant difference between the positive expression and 5-year survival rate(P>0.05); there was no obvious difference between the positive expression rate of MRP and survival rate in 45 cases patients who received adjuvant chemotherapy(P>0.05).Conclusion There is an unusual expression phenomenon of MRP in gastric carcinoma.This phenomenon illustrates that there is primary drug resistance affected by MRP in gastric carcinoma.

关 键 词：胃癌 多药耐药相关蛋白 预后 辅助化疗 

分 类 号：R735.2[医药卫生—肿瘤]