人类细胞色素酶P4502J2的研究进展  

Advances in the research on homo sapiens cytochrome P450 2J2

作　　者：罗晨辉[1] 周宏灏[1] 

机构地区：[1]中南大学临床药理研究所,湖南长沙410078

出　　处：《中国药理学通报》2004年第12期1321-1324,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金重点项目;No 3 0 13 0 2 10

摘　　要：多年来 ,对细胞色素酶P4 5 0的研究主要集中在其代谢外源性药物和毒物的方面。然而它在内源性物质 ,如类固醇、胆固醇、激素、脂肪酸和维生素等的代谢转化中也起了很重要的作用。CYP2J就是这样一种主要代谢内源性物质花生四烯酸的细胞色素酶P4 5 0超家族。人体内的CYP2J2在不久前被发现 ,它与疾病的相关性正引起研究者广泛的兴趣。本文就人类CYP2J2的组织分布、生理作用、编码基因及其基因突变等方面的研究进展作一简要综述。For many years, researches on Cytochrome P450 had been focused on their roles in exogenous drugs and poisons metabolism. In fact, Cytochrome P450 also showed significant importance in conversion of endogenous materials, such as steroids, cholesterol, hormones, fatty acid and vitamins. Among such Cytochrome P450 enzymes, CYP2J2 mainly metabolizing arachidonic acids into epoxyeicosatrienoic acids, was detected recently in human beings. The association of CYP2J2 with diseases attracts many researchers great interests. This article briefly summarized those researches of homo sapiens CYP2J2 on its distribution, physical significance, coding gene and mutants of gene as well.

关 键 词：细胞色素酶P450 CYP2J2 EETS 

分 类 号：R-05[医药卫生] R329.2