Synthesis of Diphosphites from trans,trans-Spiro[4.4]nonane-1,6-diol and Their Application in Rh-catalyzed Asymmetric Hydroformylation of Styrene  

作　　者：薛松 蒋耀忠 

机构地区：[1]Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China [2]Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China

出　　处：《Chinese Journal of Chemistry》2004年第12期1456-1458,共3页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China (No. 20202009).

摘　　要：Chiral diphosphite ligands were prepared by the reaction of (1R,5S,6R)-(trans,trans)-spiro[4.4]nonane-1,6-diol with chlorophosphites. The rhodium(I) complexes containing these ligands were tested in the asymmetric hydro-formylation of styrene and moderate enantioselectivity (up to 49% ee) was obtained. A pair of diastereomers 5a and 5b gave the opposite configuration of the product, which implies that the sense of enantioface selection is mainly dictated by the configuration of the terminal group on the ligand.Chiral diphosphite ligands were prepared by the reaction of (1R,5S,6R)-(trans,trans)-spiro[4.4]nonane-1,6-diol with chlorophosphites. The rhodium(I) complexes containing these ligands were tested in the asymmetric hydro-formylation of styrene and moderate enantioselectivity (up to 49% ee) was obtained. A pair of diastereomers 5a and 5b gave the opposite configuration of the product, which implies that the sense of enantioface selection is mainly dictated by the configuration of the terminal group on the ligand.

关 键 词：catalyst chiral diphosphite HYDROFORMYLATION 

分 类 号：O643.3[理学—物理化学]