Synthesis of Novel 1,3-Dioxolane Nucleoside Analogues  

作　　者：蔡冬梅 林昆华 李明宗 温集武 李鸿艳 尤田耙 

机构地区：[1]Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China [2]Department of Chemistry, Shanghai University, Shanghai 200436, China

出　　处：《Chinese Journal of Chemistry》2004年第12期1425-1431,共7页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China (No. 21172049).

摘　　要：Novel 1,3-dioxolane C-nucleoside analogues of tiazofurin 2-(2-hydroxymethyl-1,3-dioxolan-4-yl)-1,3-thiazole- 4-carboxamide as well as N-nucleoside analogues of substituted imidazoles 1-(2-hydroxymethyl-1,3-dioxolan- 4-yl)-4-nitroimidazole and 1-(2-hydroxymethyl-1,3-dioxolan-4-yl)-4,5-dicyanoimidazole were synthesized from methyl acrylate through a multistep procedure. Their structures were confirmed by IR, 1H NMR, 13C NMR spectra and elemental analysis.Novel 1,3-dioxolane C-nucleoside analogues of tiazofurin 2-(2-hydroxymethyl-1,3-dioxolan-4-yl)-1,3-thiazole- 4-carboxamide as well as N-nucleoside analogues of substituted imidazoles 1-(2-hydroxymethyl-1,3-dioxolan- 4-yl)-4-nitroimidazole and 1-(2-hydroxymethyl-1,3-dioxolan-4-yl)-4,5-dicyanoimidazole were synthesized from methyl acrylate through a multistep procedure. Their structures were confirmed by IR, 1H NMR, 13C NMR spectra and elemental analysis.

关 键 词：NUCLEOSIDE 1 3-dioxolane tiazofurin RIBAVIRIN IMIDAZOLE 

分 类 号：O629[理学—有机化学]