微囊化雪旺细胞移植研究进展  

The Advantage of Transplantation of Microencapsulated Schwann Cells

作　　者：马建敏[1] 刘德明[1] 

机构地区：[1]江西医学院人体解剖教研室,江西南昌330006

出　　处：《解剖科学进展》2004年第4期361-363,367,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金资助项目 (No 3 0 0 60 0 3 4);江西省自然科学基金资助项目 (No 0 14 0 12 6)

摘　　要：微囊技术为组织 /细胞移植开辟了新途径 ,它有效地避免了移植后的免疫排斥反应 ,并解决了移植物来源稀少的问题。微囊具有良好的免疫隔离作用 ,体现在对免疫活性细胞及部分细胞因子的阻挡作用 ,使移植物能存活下来并发挥其功能。雪旺细胞的分离纯化技术已日渐成熟 ,目前对微囊化雪旺细胞的研究取得了一定的进展 ,使异种雪旺细胞的移植在治疗神经损伤方面成为可能 ,并具有广阔的应用前景。A large number of potential medical applica ti ons of microencapsulated cells have been developed, which is a possible approach to overcome the problems of human organ donor shortage in transplantation and p rovide effective protections against the immune rejective reaction, so it is imp ortant to develop immunoisolation systems for transplantation of xeno-or allogr afts. Some measures have been taken to prolong allo-or xenografts survivals. Th e techniques of isolation and purification of Schwann cells have been developed, and the remarkable progress was made in the research of microencapsulated Schwa nn cells. The transplantation of xeno-or allografts Schwann cells may be possib le rat for the treatment of nerve injury.

关 键 词：雪旺细胞移植 移植物 微囊化 治疗 移植后 免疫隔离 免疫排斥反应 分离纯化技术 存活 异种 

分 类 号：Q813[生物学—生物工程] R651[医药卫生—外科学]