原发性肺恶性淋巴瘤15例临床病理分析  

Clinicopathology of primary lymphoma of lung

作　　者：李丹[1] 李甘地[1] 刘卫平[1] 杨可[1] 李俸媛[1] 廖殿英[1] 江玮[1] 

机构地区：[1]四川大学华西医院病理科,成都610041

出　　处：《山西医科大学学报》2004年第6期589-592,共4页Journal of Shanxi Medical University

摘　　要：目的　探讨原发性肺恶性淋巴瘤 (PLL)的临床病理和免疫组织化学特征。方法　回顾分析 15例原发性肺恶性淋巴瘤的临床病理特征 ,用免疫组织化学染色LsAB法 (S P法 )确定肿瘤细胞的特性 ,使用的抗体有LCA、CD2 0、CD4 5RO、CD30、CD5 6、κ、λ、CK、NSE、HMB4 5。结果　按 2 0 0 1年WHO关于淋巴造血组织肿瘤分类标准 ,确诊 15例原发性肺恶性淋巴瘤 ,均为非霍奇金淋巴瘤 (NHL)。其中 ,成熟性B细胞淋巴瘤 13例 ,全为黏膜相关淋巴瘤 (MALT淋巴瘤 )。成熟性T细胞或NK细胞淋巴瘤 2例 ,其中NK T淋巴瘤和间变性大细胞性淋巴瘤 (ALCL)各 1例。结论　许多非霍奇金淋巴瘤可原发于肺 ,必须结合病理形态特征和免疫组织化学染色进行诊断和鉴别诊断。Objective To study the clinicopathologic and immunohistochemical features of primary lymphoma of lung(PLL)and the significance of immunohistochemistry in diagnosis and differential diagnosis of PLL. Methods Fifteen patients of PLL were studied and immunochemical staining for LCA, CD20, CD45RO, CD30, CD56, κ , λ, CK, NSE and HMB45, was carried out with the LsAB methods (S-P methods). Results According to the histological pattern and immunohistochemical features, 15 patients with PLL were diagnosed as non-Hodgkin lymphoma, 13 mature B-cell lymphoma, and all were mucosa-associated lymphoid tissue lymphoma(MALT lymphoma). Two patients were diagnosed as mature T-cell or NK-cell lymphomas: one as NK/T lymphoma and another as anaplastic large cell lymphoma (ALCL). Conclusion Non-Hodgkin lymphoma can primarily occure in lung .The evaluation of pathologic features and immunohistochemistry in PLL is useful and practical for differential diagnosis.

关 键 词：肺肿瘤 淋巴瘤 免疫组织化学 诊断 鉴别 

分 类 号：R733[医药卫生—肿瘤]