去卵巢骨质疏松症大鼠模型骨密度的变化  

Changes in Bone Mineral Density in Ovariectomized Rats

作　　者：董培智[1] 曹丽梅[1] 李波[1] 

机构地区：[1]中国药品生物制品检定所药理室,北京100050

出　　处：《动物学杂志》2004年第6期87-90,共4页Chinese Journal of Zoology

摘　　要：观察3月龄SD雌鼠切除双侧卵巢29周内模型组和雌二醇组动物第三腰椎及股骨骨密度的变化,同时与假手术组比较。结果表明,SD雌性大鼠切除卵巢9周股骨骨密度明显低于假手术组(P<001),13周后腰椎骨骨密度也有显著差异(P<001),29周内模型稳定。皮下注射苯甲酸雌二醇40μgkg×2次周,在12周能够明显提高切卵巢SD大鼠的股骨骨密度并使其接近正常,16周后第三腰椎的骨密度也能够明显提高。切卵巢骨质疏松症大鼠模型治疗性给药需要大约9～13周左右模型才能成功,切除卵巢后29周内模型仍然稳定。The changes in Bone Mineral Density (BMD) were evaluated in female Sprague Dawley rats that had been ovariectomized (OVX) at 3 months old. The femoral BMD of OVX rats was significantly lower than that of the sham group ( P <0 01) 9 weeks after OVX and the BMD of lumbar spine was significantly lower than that of the sham group ( P <0 01) 13 weeks after OVX. Osteoporosis was established 9 weeks after OVX and was kept till 29 weeks. When estradiol (40?μg/kg) was administrated to osteoporosis rats subcutaneously 2 times weekly 13 weeks after OVX, the femoral BMD of osteoporosis SD rats was improved significantly and the BMD value was close to that of the sham rats 12 weeks after estradiol administration. The BMD of the lumbar spine increased significantly 16 weeks after estradiol administration.

关 键 词：骨密度 股骨 切除 大鼠模型 卵巢 骨质疏松症 腰椎 除卵 月龄 动物 

分 类 号：R58[医药卫生—内分泌]