阿扎司琼、格拉司琼预防腹腔镜胆囊切除术后恶心呕吐的疗效观察  

Clinical observation on azasetron and granisetron in preventing postoperative nausea and vomiting of cholecystomy under abdominoscope

作　　者：李振华[1] 蔡宏伟[1] 周艳平[1] 王云姣[1] 

机构地区：[1]中南大学湘雅医院麻醉科,湖南长沙410008

出　　处：《现代医药卫生》2005年第1期8-9,共2页Journal of Modern Medicine & Health

摘　　要：目的比较阿扎司琼和格拉司琼预防腹腔镜胆囊切除术后恶心呕吐的临床疗效。方法选择120例ASAⅠ～Ⅱ级择期腹腔镜胆囊切除术病人,随机将病人分为三组,在开始缝皮前静注格拉司琼(G组,n=40)3mg、阿扎司琼(A组,n=40)10mg、生理盐水(对照组,C组,n=40)。结果在术后6小时内和24小时内恶心呕吐的发生率G组(175%、325%)和A组(125%、175%)明显低于C组(400%、675%)(P<001),A组在术后6小时内恶心呕吐与G组比较差异无显著性(P>005),但在术后7～24小时内恶心呕吐的发生率明显低于G组(50%vs15.0%)(P<005)。结论阿扎司琼和格拉司琼均可显著减少腹腔镜胆囊切除术术后恶心呕吐发生率,对于预防早期恶心呕吐两者疗效相当,但阿扎司琼对晚期恶心呕吐的预防作用要优于格拉司琼。Objective:To evaluate the prophylactic effect of azasetron and granisetron on postoperative nausea and vomiting(PONV)of cholecystectomy under abdominoscope.Methods:One hundred and twenty patients,scheduled for selective cholecystectomy under abdominoscope,were randomly divided into three groups,which received an intravenous bolus of0.9%NS3ml(group placebo,n=40),granisetron3mg(group grasnietron,n=40),10mg of azasetron in3ml solution(group azasetron,n=40),respectively.Results:The incidences of PONV in granisetron group(17.5%,32.5%)and azasetron group(12.5%,17.5%)were significantly lower than those in placebo group(40.0%,67.5%)(P<0.01)in postoperative6hours and24hours.The incidence of PONVin azasetron group was significantly lower than that in granisetron group in postoperative7～24hours(5.0%vs15.0%)(P<0.05),but without significant difference between them in postoperative6hours(P>0.05).Conclusion:Both arasetron and granisetron can be used effectively to prevent PONV in cholecystectomy patients under abdominoscope,but azaˉsetron is superior to granisetron in preventing later PONV.

关 键 词：阿扎司琼 格拉司琼 术后恶心呕吐 腹腔镜胆囊切除术 发生率 预防 病人 结论 显著性 目的 

分 类 号：R730.53[医药卫生—肿瘤] R657.4[医药卫生—临床医学]