纤维蛋白溶解系统功能的研究进展  

Review on the researches of the functions of fibrinolytic system

作　　者：尹艳茹[1] 

机构地区：[1]南方医科大学分校生理学教研室,广东省广州市510315

出　　处：《第一军医大学分校学报》2004年第2期191-194,共4页Journal of Branch Campus of the First Military Medical University

摘　　要：纤维蛋白溶解系统即纤溶系统对人体血液保持流体状态与正常运行具有重要作用。研究发现纤溶系统的物质还具有很多新的生理功能。如纤溶酶原具有抑制血管内皮细胞增殖的能力 ;PAIS与t-PA的相互作用 ,动态平衡调节着滋养层细胞浸入子宫壁 ,绒毛间隙血窦中纤维蛋白的溶解等重要的生理过程 ;PAI- 1可能通过抑制肿瘤细胞凋亡而促进肿瘤细胞生长 ,是一系列肿瘤发生时的不祥预兆因子等等。因此 。Fibrinolytic system plays a crucial role in the maintenance of the blood in liquid and flowing normally. It is found that the components of fibrinolytic system have novel physiologic functions. For example, the plasminogen restrains the proliferation of blood vessels endothelial cells; PAIS and t-PA regulate embryo trophoblasts implantation, vascular remodeling, and maintenance of intervillous blood flow; PAI-1 may promote tumor growth through inhibition of apoptosis, and is a prognostic tumor-invasion factors. Thereby, it is important to further understand the fibrinolytic system.

关 键 词：T-PA UK SK PAI-1 PAI-2 纤维蛋白溶解系统功能 研究进展 血栓性疾病 

分 类 号：R364.15[医药卫生—病理学]