甲孕酮在预防化疗消化道反应中的作用  

Effect of medroxyprogesterone acetate in preventing chemotherapy-induced vomiting, nausea and anorexia

作　　者：薛英波[1] 卢文娜[1] 陈燕平[1] 

机构地区：[1]贵州省人民医院肿瘤科,贵阳市550002

出　　处：《实用诊断与治疗杂志》2005年第1期12-13,共2页Journal of Practical Diagnosis and Therapy

摘　　要：目的:比较恩丹西酮+地塞米松、恩丹西酮+地塞米松+甲孕酮(倍恩胶囊)二种止吐方案预防化疗消化道反应的疗效。方法:以顺铂或蒽环类为主化疗的患者80例,随机分为两组,每组40例,分别用上述止吐方案,观察化疗当日至化疗第4 d预防消化道反应的效果。结果:二种止吐方案对控制呕吐有效率相近,对控制恶心二种方案在第1,2 d有效率有显著差异(P<0.05),对减轻食欲不振二种方案有效率有极显著差异(P<0.01)。结论:恩丹西酮+地塞米松能很好地控制化疗所致恶心、呕吐,加用甲孕酮后疗效有所提高,特别是减轻食欲不振疗效明显优于恩丹西酮+地塞米松。Objective To compare the effect of ondandetron + dexamethasone (DXM), and ondandetron+DXM+medroxyprogesterone acetate (MPA) in preventing chemotherapy-induced vomiting, nausea and anorexia. Methods Eighty patients receiving chemotherapy on the basis of cisplatine or epirubicine in moderate dosage were randomly divided into two groups and given separately the protocol mentioned above. Results For the vomiting there was no significant difference in the two protocols of ondandetron+DXM , and ondandetron+DXM+MPA. For the nausea there was significant difference in the two protocols on the first day and second day (P<0.05). For anorexia there was very significant difference in the two protocols (P<0.01). Conclusion Ondandetron+DXM can control the vomiting and nausea induced by chemotherapy. It has better results if ondandetron+DXM combined with MPA, especially for the chemotherapy-induced anorexia.

关 键 词：化疗 恶心呕吐 恩丹西酮 地塞米松 甲孕酮 

分 类 号：R730.53[医药卫生—肿瘤]