寻常型白癜风临床特征及遗传传递方式分析  

Clinical Features and the Mode of Genetic Transmission in Vitiligo Vulgaris

作　　者：刘江波[1] 桂金萍 熊全庚 王红艳[1] 李明[1] 高敏[1] 杨杰[1] 杨青[1] 贾卫华[3] 杨森[1] 张学军[1] 

机构地区：[1]安徽医科大学皮肤病研究所暨第一附属医院皮肤科,合肥230032 [2]湖北襄樊铁路医院白癜风研究所 [3]中山大学附属肿瘤医院

出　　处：《中华皮肤科杂志》2005年第1期32-34,共3页Chinese Journal of Dermatology

基　　金：国家863基金资助项目(2001AA227031)

摘　　要：目的分析中国汉族寻常型白癜风的临床特征及家族遗传特征,探索其可能的遗传传递方式。方法以调查表的形式收集患者的临床资料及家系资料,用EpiInfo5.0及SPSS10.0软件包进行统计学分析,用SAGE3.1进行遗传传递方式的复合分离分析。结果寻常型白癜风的发病年龄为(19.02±12.58)岁,无性别差异(P=0.54);男女先证者疾病轻重程度(P=0.66)、发病季节分布(P=0.302)差异亦无统计学意义;女性患者的伴发疾病率显著高于男性(P=0.03),尤以甲亢为著(P=0.02)。患者亲属中白癜风患病率较一般人群显著增高。寻常型白癜风符合多基因累加遗传传递方式(P>0.05)。结论寻常型白癜风的发生无性别差异,但存在明显的家族聚集性,该病的发生可能是由多基因累加遗传效应及环境因素共同作用的结果。Objective To analyze the clinical features and to explore the potential mode of genetic transmission of vitiligo vulgaris in Chinese Han population. Methods Information on the clinical features and the familial history of patients with vitiligo vulgaris was collected by a uniform questionnaire. The data were inputted into a data base, then analyzed by Epi Info 5.0 and SPSS 10.0 software packages. A complex segregation analysis was conducted using the REGTL program in SAGE 3.1 package in order to propose the putative mode of genetic transmission for vitiligo vulgaris. Results The mean age of onset of vitiligo vulgaris of the males and females was about 19 years old. In the severity of the disease and the season of onset, there was no significant difference between males and females. For the patients with vitiligo vulgaris, there was a female preponderance of complicating with autoimmune disorders, especially hyperthyroidism. The prevalence rates of vitiligo in patients′ relatives were significantly higher than that in general population. The mode of transmission of vitiligo vulgaris was one of the multifactorial inheritance according to the results obtained by the complex segregation analysis. Conclusions There are no differences in the prevalence and the age of onset between males and females patients. There is a marked familial aggregation in the patients with vitiligo vulgaris. The familial clustering might result from the polygenic additive genetic background and common environmental factors. It is suggested that vitiligo vulgaris be a multifactorial complex disease.

关 键 词：白癜风 寻常型 临床特征 传递方式 多基因 遗传 疾病 学分 性别差异 结论 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]