凋亡相关bcl-2基因族在儿童神经母细胞瘤中的表达  

The Significance of Apoptosis Related gene Family bcl-2,bax in Children Neuroblastoma

作　　者：宋兰云[1] 王学文[1] 胡晓丽[1] 宁培儒[1] 

机构地区：[1]天津市儿童医院,300074

出　　处：《天津医药》2005年第1期20-21,共2页Tianjin Medical Journal

摘　　要：目的:探讨癌基因bcl鄄2及其基因族成员bax蛋白的表达水平与神经母细胞瘤(NB)临床生物学行为的关系。方法:运用免疫组化方法对25例NB中的bcl鄄2、bax蛋白表达进行检测。结果:25例NB中bcl鄄2蛋白阳性检出率为72%(18/25)。bax蛋白的阳性检出率为48%(12/25)。年龄<1岁,F型NB的bcl鄄2蛋白阳性表达明显低于年龄≥1岁、UF型(P<0.05,P<0.01)。bax蛋白在NB不同组间阳性表达差别无统计学意义。结论:bcl鄄2蛋白对判断NB的预后有重要价值。Objective: To study the prognostic effect of bcl-2 oncogene and its gene family members bax expression in children neuroblastoma(NB). Methods: Twenty-five cases of NB were studied for bcl-2 and bax protein expression with immunohistochemical method. Results: Bcl-2 protein positivity was found in 18(72%) patients,bax positivity 12(48%). Bcl-2 protein positivity of cases under 1 year of age and favourable histopathologic (F) type were significantly lower than that of case over 1 year of age and unfavourable histopathologic (UF) type (P < 0.05, P < 0.01). There was no significant difference in bax protein expression of various groups(P > 0.05). Conclusion: Bcl-2 may be useful to evaluate prognosis of NB.

关 键 词：BAX蛋白 NB 神经母细胞瘤 BCL-2蛋白 阳性表达 凋亡 BCL-2基因 结论 目的 意义 

分 类 号：R739[医药卫生—肿瘤] R730.264[医药卫生—临床医学]