非小细胞肺癌中伴神经内分泌分化及c-erbB-2表达的意义  

Significance of c-erbB-2 Expression and Neuroendocrine Differentiation in Non-small Cell Lung Carcinoma

作　　者：李军川[1] 陈廷煊[1] 

机构地区：[1]湖北荆州市第一人民医院病理科,434000

出　　处：《肿瘤防治研究》2005年第1期22-23,29,F002,共4页Cancer Research on Prevention and Treatment

摘　　要：目的探讨非小细胞肺癌(NSCLC)伴神经内分泌分化(NE)与原癌基因cerbB2表达的关系。方法观察非小细胞肺癌32例,用免疫组织化学SP法来判定神经内分泌分化及cerbB2表达特点。结果NSCLC中24例有NE分化,cerbB2在伴NE分化和无NE分化的表达阳性率比较,差异有显著性,NE分化的阳性率和癌细胞分化程度有显著性差异。cerbB2阳性在淋巴结转移组表达与无淋巴结转移组表达相比有显著性差异。结论cerbB2的过表达在非小细胞肺癌中与其侵袭性的生物学行为密切相关。cerbB2过表达可用来判断NE分化的非小细胞肺癌预后。Objective To investigate significance of c-erbB-2 expression in non-small cell lung carcinoma(NSCLC) with neuroendocrine (NE)differentiation. Methods 32 cases of NSCLC were studied with conventional histopathological and immunohistochemical stains. Results There were 75% cases of 32 NSCLC with NE.Remarkable difference was found in c-erbB-2 expression in NSCLC with NE and without NE. Conclusion Neuroendocrine differentiation of NSCLC is a strongly close correlated with c-~erbB-2 expression and Neuroendocrine differentiation of NSCLC can be the prognostic factor.

关 键 词：原癌基因C-ERBB-2 神经内分泌(NE) 分化 非小细胞肺癌(NSCLC) 预后 

分 类 号：R734.2[医药卫生—肿瘤]