伽玛刀治疗垂体瘤116例临床分析  

Clinical Study on Rotating Gamma System Radiotherapy for Treatment of Pituitary Adenoma: Experience with 116 Cases

作　　者：许自强[1] 赵普学[1] 安全[1] 

机构地区：[1]郑州铁路局中心医院伽玛刀治疗中心,河南郑州450052

出　　处：《中国神经肿瘤杂志》2004年第4期291-294,共4页Chinese Journal of Neuro-Oncology

摘　　要：垂体瘤是颅内常见的良性肿瘤,以往治疗多为手术加放疗和药物治疗。近年来,越来越多的垂体瘤患者接受了伽玛刀治疗,并取得了良好的临床效果。本文探讨伽玛刀治疗不同类型垂体瘤的方法和疗效。方法:采用OUR旋转式伽玛刀治疗垂体瘤116例,50%等剂量曲线包绕肿瘤,周边剂量12～24 Gy,平均16.8 Gy,中心剂量24～46 Gy,平均34.7 Gy,根据肿瘤体积大小和内分泌类型分组,总结各组疗效。结果:随访时间6～36月,临床+影像学随访116例,激素水平测定复查86例,症状消失/改善74例(63.8%),无变化34例(29.3%),加重8例(6.9%),肿瘤消失/缩小93例(80.2%),无变化19例(16.3%),增大4例(3.5%),3例视力减退分别于伽玛刀治疗后4月、7月行手术视神经减压,垂体低功能5例,无早期临床死亡,肿瘤控制率96.5%。结论:伽玛刀治疗垂体瘤安全、有效,不同类型的垂体瘤应制定相应合理的治疗规划。BACKGROUND & OBJECTIVE: Pituitary adenoma is one of the most common intracranial tumors that used to be treated by surgery. In recent years, gamma knife radiosurgery has emerged as an important treatment modality in the management of pituitary adenomas. In this paper, emphasis was laid upon treatment program-ming and results of Rotating Gamma System radiotherapy in different types of pituitary adenoma. METHODS: One hundred and sixteen cases of pituitary adenoma were treated with OUR Rotating Gamma System, 50% of the isodose curve surrounded the tumor. The surrounding tumor tissue received 12-24Gy, average 16.8Gy. The cen-ter received 24-46Gy, average 34.7Gy. The out comes were summarized according to the tumor volume and en-docrine type. RESULTS: All the patients were followed up for 6-36 months. The clinical symptoms were disap-peared or improved in 74 patients (63.8% ), and MR image showed tumors were disappeared or became smaller in 93(80.2%) cases. CONCLUSIONS: Gamma knife radiotherapy for pituitary adenoma is a safe and effective method. The treatment programming should be established according to the different types of pituitary adenoma.

关 键 词：伽玛刀 垂体瘤 治疗 临床分析 

分 类 号：R736.4[医药卫生—肿瘤]