Sperm quality in mice acutely treated with parathion  

作　　者：Cristian Sobarzo Eduardo Bustos-Obregon 

机构地区：[1]Faculty of Basic Sciences, Catholic University of Temuco and Biology of Reproduction Unit, Program of Morphology, ICBM, Faculty of Medicine, University of Chile. Santiage 7, Chile.,Faculty of Basic Sciences, Catholic University of Temuco and Biology of Reproduction Unit, Program of Morphology, ICBM, Faculty of Medicine, University of Chile. Santiage 7, Chile.

出　　处：《Asian Journal of Andrology》2000年第2期147-150,共4页亚洲男性学杂志（英文版）

摘　　要：Aim: To investigate the toxic effect of a single injection of the organophosphorous agropesticide, parathion, on sper-matogenesis in immature male mice. Methods: Seven-day old mice received a single injection of parathion intraperi-toneally at a dose of 1/3 LD_50. The epididymal sperm count, sperm morphology and chromatin thermal stability wereanalyzed 28 and 50 days after injection. Results: Sperm counts were decreased and teratozoospermia and thermal de-naturation of DNA increased after parathion injection. Sperm parameters were changed to a greater extent in younger an-imals, denoting a higher lability of spermatogenic process at its beginning. The damages could recover a long time afterparathion administration. Conclusion: Organophosphorous agropesticides are testicular toxicants, eliciting reversiblecytotoxic and cytogenetic alterations in germ cells.Aim: To investigate the toxic effect of a single injection of the organophosphorous agropesticide, parathion, on sper-matogenesis in immature male mice. Methods: Seven-day old mice received a single injection of parathion intraperi-toneally at a dose of 1/3 LD_50. The epididymal sperm count, sperm morphology and chromatin thermal stability wereanalyzed 28 and 50 days after injection. Results: Sperm counts were decreased and teratozoospermia and thermal de-naturation of DNA increased after parathion injection. Sperm parameters were changed to a greater extent in younger an-imals, denoting a higher lability of spermatogenic process at its beginning. The damages could recover a long time afterparathion administration. Conclusion: Organophosphorous agropesticides are testicular toxicants, eliciting reversiblecytotoxic and cytogenetic alterations in germ cells.

关 键 词：EPIDIDYMIS SPERMATOZOA organophosphorous compounds agropesticides SPERMATOGENESIS 

分 类 号：R96[医药卫生—药理学]