中药复方活性筛选形式与技术研究进展  

Progress in Study on Screening Forms and Technology of Activity of Compound Chinese Medicines

作　　者：王忠[1] 刘建勋[1] 肖诗鹰[2] 王永炎[3] 

机构地区：[1]中国中医研究院西苑医院,北京100091 [2]科技部21世纪议程管理中心,北京100091 [3]中国中医研究院,北京100700

出　　处：《世界科学技术-中医药现代化》2004年第5期51-55,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家重点基础研究发展规划(G19990544)方剂的关键科学问题研究;负责人:王永炎国家高技术研究发展计划(2003AA2Z2022)生物芯片在中药有效组分抗脑缺血机制及筛选中的应用;负责人:王忠

摘　　要：药物发现是新药研究的重要过程,其中药物活性筛选是决定新药研究成败的关键。本文分析了目前中药复方活性筛选的8种形式,并按历史进程将筛选技术分为传统筛选技术与现代筛选技术,简述了临床前活性药物优化技术、候选药选择技术、分离技术、分子设计、分子水平筛选、生物芯片技术、药物基因组学、药物相互作用分析技术(BIA)、化学和生物信息学结合、中药复方多层区组筛选模式(MBAS模式)等现代筛选技术的特征,并探讨药物发现策略的改变和新技术应用对于中药复方活性筛选研究进程的影响。The discovery of medicines is an important process in the study of new medicines, in which the screening of the activity of medicines constitute the master key to the success of the study on a new medicine. This article analyzes the eight forms used in the screening of the activity of compound Chinese medicines at present; divides screening technology into the traditional and modern ones; generally presents the characteristics of such modern screening technologies as the technology for the optimization of pre - clinical active medicines, the technology for the selection of medicines to be screened, the separation technology, the technology for molecule design, the technology for screening at molecular level, the technology for bio - chips, science of medicine genomes, analytical technology for the interreaction of medicines, the technology for the combination of chemistry and bio - information and the MBAS; and explores the impact of the change in the strategy for the discovery of new medicines and the application of new technologies on the progress in the study on the screening of the activity of compound Chinese medicines.

关 键 词：中药复方 活性筛选 新药研究 药物发现 药物基因组学 药物相互作用 改变 筛选技术 选择技术 中药物 

分 类 号：N94[自然科学总论—系统科学] R285[医药卫生—中药学]