恶性肿瘤患者TXB_2、6-Keto-PGF_(1α)、GMP-140测定及临床意义  

Determination of TXB_2,6-Keto-PGF_(1α) and GMP-140 in Patients with Carcinoma and Its Clinical Significance

作　　者：邵慧珍[1] 陈怡群[1] 许峰[2] 张慧娟[2] 支立民 黄霞萍 王鸿利 

机构地区：[1]上海第二医科大学上海血液学研究所 [2]上海第二医科大学 [3]瑞金医院止血与血栓研究室

出　　处：《上海第二医科大学学报》1993年第1期1-4,共4页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：本文选择TXB_2、6-Keto-PGF_(1α)和GMP-140对138例消化道癌,42例非消化道癌及30例正常人进行检测和分析。结果:(1)消化道癌组(除食管癌来转移组外)血浆TXB_2,6-Keto-PGF_(1α)均比正常组有明显升高(P<0.05～0.001),TXB_2转移组明显高于未转移组(P<0.001),;(2)消化道痛与非消化道癌转移组TXB,、6-Keto-PGF~。lj正常组相比均有非常垃著升高(P<0.001);(3)消化道癌手术切除组(不论伴或不伴化疗),与未治疗组相比,TXB_2、6-Keto-PGF_(1α)均有所下降;(4)胃癌、肠癌治疗组与未治疗组GMP-140与正常组栩比有怍常显著升高(P<0.001)。TXB_2, 6-Keto-PGF_(1α), and GMP-140 were determined in 180 patients of carcinoma, among them 138 were gastrointestinal (Group A), and 42 were extra-gastrointestinal (Group B). Group C consisted of 30 normal adults serving as control. The results showed that the plasma TXB_2 and, 6-Keto-PGF_(1α) levels were significantly higher in Group A patients (with the exception of those esophageal carcinoma without metastasis) vs control (P<0.05-0.001). The values of TXB_2 in Group A patients that the tumor had already metastasized was significantly higher than those without metastasis (P<0.001). The values of TXB_2 and, 6-Keto-PGF_(1α) in both Group A and B were much higher vs control (P<0.001), but the values in Group A pastients having undergone surgical resection were lower than those not operated (P<0.001) no matter whether chemotherapy was used or not. The value of GMP-140 was much higher in patients with gastric and colonic carcinoma whether treated or not vs control (P<0.001).

关 键 词：血栓素B2 前列环素 肿瘤转移 

分 类 号：R73－37[医药卫生—肿瘤]