福赛斯拟杆菌在感染根管内定植及其与临床症状的关系  

Association Between Bacteroides forsythus in the Infected Root Canals and Clinical Symptoms of Chronic Apical Periodontitis

作　　者：黄定明[1] 付春华[2] 周学东[1] 

机构地区：[1]四川大学华西口腔医学院牙体牙髓病研究室,成都610041 [2]四川大学口腔生物医学工程教育部重点实验室

出　　处：《四川大学学报（医学版）》2005年第1期46-49,共4页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金 (批准号 3 0 171175 )资助

摘　　要：目的　了解福赛斯拟杆菌在慢性根尖周炎患牙根管内定植情况 ,探讨该菌与慢性根尖周炎临床症状间的关系。方法　收集 38例慢性根尖周炎患牙根管标本 ,采用 16 S r DNA PCR方法检测福赛斯拟杆菌在根管内分布情况 ,单因素相关分析福赛斯拟杆菌在根管内定植与慢性根尖周炎疼痛、叩痛、瘘道和肿胀间关系。结果　福赛斯拟杆菌在 38例慢性根尖周炎根管内检出 10例 ,检出率为 2 6 .3% ,与慢性根尖周炎的急性发作临床症状疼痛、叩痛、肿胀呈正相关关系 (OR分别为∞、9.0、12 .0 ) ,有统计学意义 (P<0 .0 5 ) ,与瘘道不存在相关关系 (OR=1.33)。结论　福赛斯拟杆菌能定植于根管内 。Objective To investigate the distribution of Bacteroides forsythus in root canals with chronic apical periodontitis and to determine its associations with clinical symptoms. Methods Thirty- eight tooth root canals from 31 subjects were studied with a 16S rDNA-directed polymerase chain reaction (PCR). These teeth were classified into symptomatic and asymptomatic groups according to the clinical symptoms and signs, including spontaneous pain, percussion pain, sinus tract and swelling, respectively. Results Ten of the 38 root canal samples were positive for B. forsythus. The prevalence of B. forsythus was 26.3% for 38 root canals, 45.5% for spontaneous pain group, 39.1% for percussion pain group, 29.4% for sinus tract group, 42.9% for swelling group, respectively. Significant positive associations were observed between B. forsythus in infected root canals and the spontaneous pain, percussion pain, and swelling of apical periodontitis, respectively (OR=∞, 9,12; P<0.05). There was no significant association between B. forsythus and sinus tract of apical periodontitis (OR=1 33). Conclusion B. forsythus colonized in the infected root canals. It is the putative pathogen of apical periodontitis.

关 键 词：福赛斯拟杆菌 感染根管 慢性根尖周炎 PCR 

分 类 号：R781.42[医药卫生—口腔医学]