Survivin在人脑胶质瘤中的表达及意义  

Expression of Survivin and Its Significance in Human Brain Glioma

作　　者：甄海宁[1] 章翔[1] 杨彤涛[2] 胡佩臻[3] 付洛安[1] 马福成[3] 王西玲[1] 梁景文[1] 

机构地区：[1]第四军医大学西京医院全军神经外科研究所,西安市710033 [2]西安市唐都医院全军骨科中心 [3]第四军医大学基础部病理学教研室

出　　处：《中国肿瘤临床》2005年第1期6-8,12,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金资助(编号:39970752)

摘　　要：目的:探讨凋亡蛋白抑制因子Survivin在人脑胶质瘤中的表达水平及与脑胶质瘤发生发展的关系。方法:采用免疫组化SABC方法检测Survivin蛋白在83例脑胶质瘤和12例正常脑组织标本中的表达水平。结果:Survivin在脑胶质瘤及正常脑组织中的表达阳性率及免疫反应评分(IRS)分别为57.8%、3.75±3.89和8.3%、0.17±0.58,两者间表达阳性率及IRS均有极显著差异(P均<0.01)。Ⅰ～Ⅳ级以及良、恶性脑胶质瘤Survivin表达阳性率分别为29.4%、44.0%、72.2%、82.6%和38.1%、78.0%,在脑胶质瘤不同病理级别以及不同恶性度间Survivin表达阳性率均有极显著差异(P=0.002,P<0.01)。Ⅰ～Ⅳ级以及良、恶性脑胶质瘤SurvivinIRS分别为1.29±2.62、2.56±3.44、4.78±3.89、6.04±3.78和2.05±3.16、5.49±3.83,在脑胶质瘤不同病理级别以及不同恶性度间SurvivinIRS也有极显著差异(P均<0.01)。结论:Survivin在脑胶质瘤中高表达,且随脑胶质瘤病理级别的增高而表达增强,Survivin在脑胶质瘤发生发展过程中具有重要作用。Objective: To discuss the expression level of inhibitor of apoptosis protein survivin in human brain glioma and its relationship between tumorigenesis and progression of brain glioma. Methods: Expression level of survivin protein was investigated by immunohistochemistry SABC method in 83 cases of brain glioma and 12 cases of normal brain tissue. Results: It was 57.8%, 3.75±3.89 and 8.3%, 0.17±0.58, respectively that the positive expression percent and immunoreactivity score (IRS) of survivin in brain glioma and normal brain tissue. There was specially significant difference(both P<0.01), respectively between the positive expression percent and IRS of survivin in brain glioma and those in normal brain tissue. It was 29.4%, 44.0%, 72.2%, 82.6% and 38.1%, 78.0% respectively that the positive expression percent of survivin in Ⅰ to Ⅳ grade brain glioma and benign and malignant brain glioma. There were specially significant difference(P=0.002<0.01, P<0.01) respectively among the positive expression percent of survivin in Ⅰ to Ⅳ grade brain glioma, and between the positive expression percent of survivin in benign brain glioma and that in malignant brain glioma. It was 1.29±2.62, 2.56±3.44, 4.78±3.89, 6.04±3.78 and 2.05±3.16, 5.49±3.83 respectively that the survivin IRS in Ⅰ to Ⅳ grade brain glioma and benign and malignant brain glioma. There were specially significant difference(both P<0.01) respectively among the survivin IRS in Ⅰ to Ⅳ grade brain glioma, and between the survivin IRS in benign brain glioma and that in malignant brain glioma too. Conclusion: Survivin is overexpressed in brain glioma, and survivin expression is improved with the increasing of pathological grade of brain glioma. Survivin plays an important role in tumorigenesis and progression of brain glioma.

关 键 词：Survivin凋亡蛋白抑制因子 胶质瘤 免疫组化 

分 类 号：R739.41[医药卫生—肿瘤]