口腔畸胎样囊肿临床病理与免疫组化研究  

Clinicopathological and immunohistochemical study of oral teratoid cyst

作　　者：申静[1] 陈新明[1] 汪说之[1] 王丽[1] 熊世春[1] 

机构地区：[1]武汉大学口腔医学院口腔生物医学工程教育部重点实验室,430079

出　　处：《中华口腔医学杂志》2005年第1期62-66,共5页Chinese Journal of Stomatology

摘　　要：目的　分析 31例口腔畸胎样囊肿的临床病理及免疫组化特点。方法　复习武汉大学口腔医学院 196 3至 2 0 0 3年病理档案资料及切片 ,31例符合Meyer的口腔畸胎样囊肿诊断标准。全部病例行组织学、组织化学和角蛋白免疫组织化学研究。结果　本组病例约占同期颌面部软组织囊肿的 1 85 %。 31例中 ,儿童为 2 7例 ,其中 2 4例为先天性 ,男女比为 1∶0 5 5 ;口底和舌部分别为 2 2例和 8例 ;突出的临床特征为膨胀性生长 ;手术完整摘除 ,预后好。组织学观察该囊肿除复层鳞状上皮衬里外 ,还有呼吸道上皮和 (或 )胃肠上皮 ,其中 8例含单层立方上皮。角蛋白免疫组化结果显示 ,AE1/AE3在 4种上皮中均为阳性表达。AE1、CK8/ 18和CK7分别在少数复层鳞状上皮基底层和表层表达 ,所有复层鳞状上皮基底层表达CK19,而AE1、CK7、8/ 18和CK19在其余 3种上皮中均呈阳性表达。CK16在 4种上皮中均呈弱阳性表达 ,CK2 0仅在胃肠上皮呈阳性表达。结论　口腔畸胎样囊肿主要发生于儿童 ,口底和舌部为好发部位 ,镜下组织结构多样 ,角蛋白标记结果显示囊肿不同的上皮成分与机体相应部位的上皮表型相似 。Objective To investigate clinicopathological and immunohistochemical features of 31 cases of oral teratoid cyst.Methods Thirty one cases of oral teratoid cyst according with Meyer′s diagnosis criteria were retrospectively studied and their histochemistry and immunohistochemistry were performed from the files of Department of Pathology, School of Stomatology, Wuhan University between 1963 and 2003. Results Twenty seven cases (87 10%) were children, and twenty four cases were congenital. The ratio of male to female was 1∶0 55, and the affected sites were floor of mouth(22 cases) and tongue(8 cases). Clinical findings were nonspecific, and prognosis was good following complete excision. Histology indicated that squamous 、respiratory and/or gastrointestinal epithelium consistiuted basic structure of teratoid cyst in addition to simple cuboidal epithelium in 8 cases. Antibody against AE1/AE3 was strongly expressed and CK16 was weak in four types of epithelial lining of oral teratoid cyst. Expression of AE1、CK7、8/18、19 varied in superficial, suprabasal and basal cells of squamous epithelium but were strong in respiratory, gastrointestinal and simple columnar epithelium; only gastrointestinal epithelium expressed CK20 heterogeneously.Conclusions Oral teratoid cyst showed the highest incidence in children, and floor of mouth and tongue were mostly affected sites. Features of histology were complex, and immunohistochemistry indicated that epithelium of oral teratoid cyst shared similar patterns of cytokeratin with counterpart of normal tissues, showing different origin and differentiation of epithelial lining of the present cyst.

关 键 词：囊肿 鳞状上皮 口腔 畸胎 阳性表达 免疫组化 角蛋白 学院 结论 档案资料 

分 类 号：R782[医药卫生—口腔医学]