31例颌骨中心性巨细胞肉芽肿的临床病理研究  

Central giant cell lesions of the jaws: a clinicopathological study of 31 cases

作　　者：刘波[1] 于世凤[1] 吴运堂[2] 庞淑珍[1] 

机构地区：[1]北京大学口腔医学院口腔病理研究室,100081 [2]北京大学口腔医学院口腔放射科,100081

出　　处：《中华口腔医学杂志》2005年第1期67-69,共3页Chinese Journal of Stomatology

基　　金：国自然科学基金资助项目(39830430)2004-04-02

摘　　要：目的　观察分析颌骨中心性巨细胞肉芽肿 (CGCG)的临床病理学特点及病变生物学行为间的关系 ,探讨颌骨CGCG的性质及诊断。方法　采用组织病理学方法 ,结合临床随访对比分析 31例颌骨CGCG的临床病理学特点及其与病变性质的关系。结果　 31例颌骨CGCG以 30岁以下的女性多见 ,病变多见于下颌 ,X线表现无特异性。病变中的多核巨细胞 (MGC)分布较不均匀 ,核数较少 ,以 10～ 19个核多见 ,病变出血明显 ,纤维成分丰富 ,常有含铁血黄素沉积 ,骨及类骨质多见。比较病变复发组与非复发组间的临床病理学特点 ,结果提示差异无统计学意义。根据临床和X线特点病变分为侵袭组与非侵袭组 ,侵袭组与复发关系密切。结论　颌骨CGCG是一种非瘤性病变 ,在病变性质上有别于骨巨细胞瘤 ,其病理学特点在两者的鉴别上缺乏客观标准并且与其生物学行为无关 。Objective To study the clinicopathologic features of central giant cell granuloma (CGCG) of the jaws and the relationship between the pathologic features and its clinical behavior Methods Histologic, radiographic and follow up information for 31 cases of central giant cell granuloma were reviewed The histopathologic patterns were analyzed between nonrecurrent and recurrent cases for which the following up information was available Results The majority of the giant cell granuloma of the jaws occurred in patients under 30 with a predilection of females and mostly were involved in the mandible The radiographic features of CGCG non specific The multinucleated giant cell scattered unevenly, the numbers of the nuclei were few and mostly 10 19 The marked fibrosis, the multiple area of hemorrhage, abundant hemosiderin and newly formed bone were always present in the lesions No significant difference exited between the recurrence and nonrecurrence groups in the pathologic features The patients with aggressive behavior showed more consistent with the recurrence Conclusions CGCG was a non neoplastic lesion of the jaws which was different from the giant cell tumor It was difficult to distinguish between the CGCG and giant cell tumor(GCT), and to predict its clinical behavior only by the histopathological patterns It was helpful to combine the clinical presentation of CGCG with its treatment

关 键 词：颌骨 巨细胞 中心性 肉芽肿 临床病理学 病变 临床病理研究 特点 结论 客观标准 

分 类 号：R782[医药卫生—口腔医学]