重组人表皮生长因子治疗外伤性角膜上皮缺损  

The clinical observation of effect of recombinant human epidermal growth factor(rhEGF)on traumatic corneal epithelial defect

作　　者：班胜刚[1] 李永均 卢荣强[1] 蒋林志[1] 黄明汉[1] 

机构地区：[1]广西医科大学眼科中心,广西南宁530021 [2]桂平市中医院眼科,广西桂平537200

出　　处：《眼外伤职业眼病杂志》2005年第1期26-27,共2页Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries

摘　　要：目的　评价重组人表皮生长因子 (rhEGF)滴眼液治疗外伤性角膜上皮缺损的临床疗效。方法　观察 84例外伤性角膜上皮缺损病例 ,随机分成rhEGF滴眼液治疗组和常规治疗对照组 (0 3 %氧氟沙星滴眼液 )各 42例。治疗组用rhEGF滴眼液 ,对照组用 0 3 %氧氟沙星滴眼液 ,每日滴眼 4次 ,共 10天。隔日观察上皮缺损修复情况。结果　rhEGF治疗外伤性角膜上皮缺损的有效率明显高于常规治疗对照组 ,两者差异有非常显著意义 (P <0 0 1)。结论　rhEGF滴眼液治疗外伤性角膜上皮缺损能有效地促进角膜上皮缺损的修复。Objective To evaluate the clinical value of re co mbinant human epidermal growth factor (rhEGF) eye drops for traumatic corneal ep ithelial defect (TCED).Methods 84 case with TCED were randomly divided into two grorps:42 were treated by rhEGF eye drops,42 were treated by 0 3% ofloxacin eye drops.Two groups were treated with rhEGF or 0 3% ofloxacin e ye drops separately for q.i.d.Treatment course was 10 days.Epithelial defect res toration were observed on the every other day.Results The effec t of rhEGF eye drop was prior to that of 0 3% ofloxacin eye drops in TCED.The d ifference was significant (P<0 01) in two groups.Conclusion The rhEGF eye drops is reliable and safe for TCED.It can improve the healing of TCED effectively.

关 键 词：重组人表皮生长因子 角膜上皮缺损 

分 类 号：R779.1[医药卫生—眼科]