脑热清对EP性发热家兔下丘脑及脑脊液cAMP含量的影响  

Effect of naoreqing oral liquid on cAMP contents of hypothalamus and cerebrospinal fluid in endogenous pyrogen-induced febrile rabbits

作　　者：岳晓莉[1] 蒋玉凤[1] 刘智勤[1] 樊永平[2] 王文荣[1] 任丽薇[1] 黄启福[1] 胡以明[2] 

机构地区：[1]北京中医药大学病理教研室,北京100029 [2]中国医学科学院北京天坛医院,北京100050

出　　处：《中国病理生理杂志》2005年第1期172-174,共3页Chinese Journal of Pathophysiology

基　　金：北京市科委资助课题(No.954024200)

摘　　要：目的探讨脑热清(NRQ)口服液的解热机制。方法复制内生致热原性发热家兔模型,观察NRQ对体温的影响,并利用放射免疫法检测下丘脑及脑脊液cAMP的含量。结果NRQ对家兔内生致热原性发热有显著的解热作用(P<001);能够明显降低下丘脑及脑脊液中cAMP的含量(P<001)。相关分析显示,4组家兔的体温变化与下丘脑cAMP含量呈明显正相关(r=0899,P<001);下丘脑与脑脊液cAMP含量变化亦呈显著正相关(r=0971,P<001)。结论抑制下丘脑和脑脊液中cAMP含量的升高,可能是脑热清的解热机制之一。AIM: To investigate the antipyretic mechanism of Naoreqing (NRQ) oral liquid, a Chinese medicine. METHODS: ① Fever models of rabbits were established by intravenous. injection of endogenous pyrogen (EP). ② The antipyretic action of NRQ were observed. ③ cAMP contents in the hypothalamus (HP) and the cerebrospinal fluid (CSF) were determined by radioimmunoassay. RESULTS: ① NRQ obviously reduced body temperature of febrile rabbits induced by EP (P<0.01). ② Reversed contents of cAMP in HP and in CSF were observed (P<0.01). ③ Correlation analysis indicated that contents of cAMP (r=0.899, P<0.01) in HP were positively correlated with the change of body temperature in rabbits. The contents of cAMP in HP also correlated with those in CSF (r=0.971,P<0.01). CONCLUSION: NRQ may exert its antipyretic effect in rabbits by inhibiting the increase in content of cAMP in HP and CSF. [

关 键 词：内生致热原 发热 环AMP 脑清热 

分 类 号：R364.6[医药卫生—病理学]