结缔组织生长因子促纤维化作用及其表达调节的研究进展  

The mechanism of profibrotic effect of connective tissue growth factor

作　　者：杨敏[1] 黄海长[1] 王海燕[1] 

机构地区：[1]北京大学第一医院肾脏内科肾脏病研究所,北京100034

出　　处：《中国病理生理杂志》2005年第1期199-202,208,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(30270612)

摘　　要：Connective tissue growth factor (CTGF) has recently received much attention as a possible key determinant of progressive fibrosis. It promotes tissue fibrosis through different pathways, such as cell proliferation, extracellular matrix accumulation and cell transdifferentiation. A number of regulators of CTGF expression have been identified, including transforming growth factor β, vascular endothelial growth factor, tumor necrosis factor α, etc. The mechanism of profibrotic effect by CTGF was reviewed. [Connective tissue growth factor (CTGF) has recently received much attention as a possible key determinant of progressive fibrosis. It promotes tissue fibrosis through different pathways, such as cell proliferation, extracellular matrix accumulation and cell transdifferentiation. A number of regulators of CTGF expression have been identified, including transforming growth factor β, vascular endothelial growth factor, tumor necrosis factor α, etc. The mechanism of profibrotic effect by CTGF was reviewed. [

关 键 词：结缔组织生长因子 纤维化 转化生长因子Β 

分 类 号：R363[医药卫生—病理学]