心肌细胞钙火花  

Ca^(2+) sparks in cardiac myocytes

作　　者：张广钦[1] 程和平[2] 

机构地区：[1]中国药科大学药理学研究室,江苏南京210009 [2]北京大学生物膜与膜生物工程国家重点实验室

出　　处：《中国药理学通报》2005年第1期23-26,共4页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展规划资助课题(NoG2000057002)

摘　　要：心肌细胞钙火花是肌浆网上一个或几个成簇状分布的RyR所产生的局部钙释放,可通过单个L 型钙通道开放所触发或自发发放。钙火花呈随机发放,出现在Z线附近,其动力学特征受多种因素的调节。此外,T 型钙电流、Na+ /Ca2+交换、ICa(TTX)和IP3 等也是钙火花触发的来源。In cardiac myocytes, Ca 2+ sparks origining fr om a single RyR or a few RyRs are triggered by a single L-type Ca 2+ channel or occur spontaneously. Ca 2+ sparks constitute the elementary local Ca 2+ release events from the SR. Ca 2+ sparks occur at Z-lines and rando mly distribute at different locations, the characteristics of the kinetics are r egulated by many factors. In addition, I Ca.T, Na+/Ca 2+ exchang e, I Ca(TTX) and IP 3 are other putative sources of Ca 2+ that tr igger SR Ca 2+ release.

关 键 词：钙火花 心肌细胞 

分 类 号：R-05[医药卫生] R322.11