多肽ND100的抗肿瘤活性研究  

The antitumor activity of ND 100 peptide

作　　者：张冬梅[1] 陈钧辉[1] 李俊[1] 王新昌[1] 

机构地区：[1]南京大学生物化学系医药生物技术国家重点实验室,江苏南京210093

出　　处：《中国药理学通报》2005年第1期114-116,共3页Chinese Pharmacological Bulletin

摘　　要：目的　研究多肽ND100的抗肿瘤活性。方法　用液相法人工合成了抗肿瘤八肽ND100,分子量为 846 9。测定了ND100对 3种小鼠移植性肿瘤的抑制作用,并研究了ND100对小鼠红细胞和白细胞数量的影响。结果　体内抑瘤试验表明,ND100对小鼠H22肝癌、小鼠Lewis肺癌和小鼠S180肉瘤的生长均有明显抑制作用,有效剂量为 2 5mg·kg-1,当使用高剂量时(15mg·kg-1 )时,对 3种小鼠移植性肿瘤的抑制率达 0 70以上,且具有剂效关系。ND100对小鼠红细胞和白细胞的数量均无影响。结论　ND100具有明显的体内抗肿瘤活性。Aim To study the antitumor activity of ND 100. Meth od s ND 100 containing 8 amino acid residues was synthesized by solution phase methods. The molecular weight of ND 100 was 846.9. The inhibition of tumorigen esis in vivo was tested by treatment on tumor mice, meanwhile the effect of ND 100 on the numbers of erythrocyte and leukocyte was measured. Results ND 100 exerted strong dose-dependent inhibition on the growth of H22 hepto ma, S180 sarcoma and Lewis lung carcinoma. The least efficient dose was 2.5 mg ·kg -1. When higher dose (15 mg·kg -1) was used, the inhibition ra te of these 3 kinds of tumors reachesd above 70%. ND 100 had no effect on erythr ocyte and leukocyte of mice. Conclusion ND 100 has strong antitumor a ctivity in vivo.

关 键 词：多肽ND100 液相合肽 抗肿瘤活性 

分 类 号：R-332[医药卫生] R329.24