头孢拉定胶囊的近红外漫反射光谱法测定  

Determination of Cefradine Capsules by Near Infrared Spectroscopy

作　　者：潘颖[1] 沈漪[1] 项竞佐[1] 刘全 

机构地区：[1]上海市药品检验所,上海200233 [2]美国Thermo Nicolet仪器公司上海代表处,上海200031

出　　处：《中国医药工业杂志》2005年第1期32-35,共4页Chinese Journal of Pharmaceuticals

摘　　要：采用近红外(NIR)漫反射光谱法对头孢拉定胶囊进行快速定量分析。按处方配制头孢拉定含量5.01%～91.24%的30个实验室样品,并收集来源于7个厂家的49批市售产品,采集其NIR光谱。采用偏最小二乘回归法建立NIR光谱信息与样品组成间的定量分析模型,模型对21个验证样品的的预测均方差RMSEP为1.35%,预测值与理论值的相关系数为0.9968,平均加样回收率为99.4%,RSD为1.3%。A near infrared (NIR) spectroscopy was used to determine the content of cefradine capsules. Thirty samples with cefradine contentfrom 5.01% to 91.24% were prepared in thelaboratory,and 49 samples on the marketfrom 7 different factorieswere collected. The NIR spectra werecollected on an Antaris FT-NIRanalyzer. Thepartial least squares regression (PLSR) algorithm was used to build the calibration model. The model was validated by other 21 samples. The root mean square error of prediction (RMSEP) was 1.35%. The correlation coefficient between the true value and prediction value was 0.9968.The average recovery was 99.4%(RSD 1.3%).

关 键 词：头孢拉定 近红外漫反射光谱法 偏最小二乘回归 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.33[化学工程—制药化工]