晚期胃肠道癌应用Melodie泵时辰化疗的临床研究  

Clinical study of chrono-chemotherapy for advanced gastrointestinal cancers by melodie infusion pump

作　　者：何流[1] 周荣平[1] 何爱娣[1] 王剑[1] 王义兆[1] 王琪[1] 卞仕 

机构地区：[1]云南京市江宁医院肿瘤科,江苏南京211100

出　　处：《肿瘤防治杂志》2005年第2期114-116,共3页China Journal of Cancer Prevention and Treatment

摘　　要：目的:研究晚期胃肠道癌应用Melodie泵时辰化疗的近期疗效和耐受性。方法:晚期胃肠道癌患者共42例,应用配对设计,随机分为时辰化疗组和常规化疗组各21例。时辰化疗组:应用法国AGETTANT公司生产的Melodie多通道编程输液泵给药:氟尿嘧啶(5FU)500mg/(m2·d);醛氢叶酸(CF)60mg/(m2·d);奥沙利铂(LOHP)30mg/(m2·d)。LOHP给药的浓度高峰为16:00,5FU/CF为04:00。4d为1个周期,休息10d进行下1个周期。常规化疗组:LOHP130mg/m2静脉滴入,第1d;CF200mg/m2静脉滴入2h,接用5FU400mg/m2静脉推注,继以5FU16g/m2恒速静脉滴入22h,d1、d2,14d为1个周期。化疗2个周期以上评定近期疗效及毒副反应。结果:42例晚期胃肠道癌患者共化疗109个周期,平均每例255个周期,总有效率为595%(25/42)。其中,时辰化疗组和常规化疗组的近期有效率分别为762%(16/21)、429%(9/21),疗效差异有统计学意义,P<005。不良反应主要为胃肠道反应、末梢神经炎、骨髓抑制及口腔炎等。时辰化疗组的各种毒副反应均较常规化疗组轻,其中口腔炎的发生率分别为95%、381%,两组差异有统计学意义,P<005。结论:LOHP、5FU和CF三药采用多通道编程输液泵时辰化疗对晚期胃肠道癌的有效率高,耐受性好,值得继续研究。OBJECTIVE:To evaluate the efficacy and toxicity of chrono-chemotherapy for advanced gastrointestinal cancers by melodie infusion pump. METHODS: Forty-two patients of advanced gastrointestinal cancers were randomly assigned to receive chrono-chemotherapy (5-FU 500 mg/(m2·d), d 1-d 4; CF 60 mg/(m2·d), d 1-d 4; L-OHP 30 mg/(m2·d), d 1-d 4; the time of the highest plasma drug levels was 16:00, 04:00 and 04:00, every two week) or common chemotherapy (L-OHP 130 mg/m2,iv.gtt.2 h, d 1; CF 200 mg/m2 iv.gtt.2 h, d 1-d 2; 5-FU 400 mg/m2 iv, 5-FU 1.6 g/m2 continuous infusion, 22 h, d 1-d 2; every two week). After two cycles, the efficacy and toxicity were evaluated. RESULTS: The overall response rate was 59.5%. The response rate of patients in chrono-chemotherapy group and comparison group were 76.2%(16/21)and 42.9%(9/21), respectivel. There were a statistic significance, P<0.05. The primary toxicities were digestive tract toxicity, end-brush neurotoxicity, myelosuppression and stomatitis. The toxicities of chrono-chemotherapy group were slighter than those of the comparison group, and the difference about stomatitis between the two groups had statistic significance (9.5%, 38.1%,P<0.05). CONCLUSIONS: The treatment of chronomodulated oxaliplatin combined fluorouracil and leucovorin for advanced gastrointestinal cancers has higher efficacy. The side effect in endurable. It is necessssary to carry out deep study on. Chin J Cancer Prev Treat,2005,12(2):114-116

关 键 词：胃肿瘤/药物疗法 氟尿嘧啶/治疗应用 多剂联用/治疗应用 药物疗法 联合 

分 类 号：R735[医药卫生—肿瘤]