宫颈病变组织中E-cad和β-cat的表达及其意义  

Clinical significance of E-cad and β-cat expressions in CIN and cervical squamous cell carcinoma

作　　者：丁晖[1] 吴宜林[1] 刘凤英[1] 张志胜[1] 

机构地区：[1]中南大学湘雅二医院妇科,湖南长沙410011

出　　处：《肿瘤防治杂志》2005年第1期52-55,共4页China Journal of Cancer Prevention and Treatment

摘　　要：目的:研究上皮性钙黏附蛋白 (epithelial cad,E cad)和β 连接素(β catenin,β cat)在宫颈上皮内瘤样病变 (cervicalintraepithelialneoplasia,CIN)和 宫颈鳞癌中的表达及其意义。方法:应用 SP法检测E cad和β cat在正常宫颈上 皮、CINⅠ级、CINⅡ～Ⅲ级及宫颈鳞癌组 织的表达。结果:正常宫颈中E cad和β cat为膜表达。E cad表达在正常宫颈 CINⅠ级、CINⅡ～Ⅲ级和宫颈鳞癌中分别 为86%(12/14)、82%(9/11)、54%(7 13)和21%(8/38);β cat膜表达率分别为 79%(11/14)、64%(7/11)、23%(3/13)和 11%(4/38);E cad表达在正常宫颈与鳞 癌之间、CINⅠ级与鳞癌之间的差异有统 计学意义,P<0.05;在鳞癌的不同病理学 分级和肌层浸润深度之间的差异有统计 学意义,P<0.05。β cat表达在正常宫颈 与CINⅡ～Ⅲ级、宫颈鳞癌以及CINⅠ级 与鳞癌之间差异有统计学意义,P<0.05 在宫颈鳞癌的不同病理分级之间差异有 统计学意义,P<0.05。宫颈鳞癌中,E cad与β cat的表达形式具相关性,P< 0.001。结论:E cad和β cat异常表达是 宫颈上皮性肿瘤进展的早期事件;在宫颈 浸润性鳞癌中,它们的异常表达可能与肿 瘤的侵袭潜能有关。OBJECTIVE:To study E-cad and β-catenin (β-cat) expressions and their clinical significance in cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma.METHODS:E-cad and β-cat expressions were investigated by the SP method in normal cervical epithelia,low-grade CIN, high-grade CIN and cervical squamous cell carcinoma.RESULTS:In normal cervical epithelia,E-cad and β-cat expressed at the membranes. E-cad membranous expression rates in normal cervical epithelia, CIN Ⅰ, CIN Ⅱ-Ⅲ and squamous cell carcinomas were 86%(12/14), 82%(9/11), 54%(7/13) and 21%(8/38), respectively; β-catmembranous expression rates were 79%(11/14), 64%(7/11), 23%(3/13) and 11%(4/38), respectively. The difference of E-cad expression between normal cervical epithelia and invasive squamous cell carcinoma was as statistically significant as that between CINⅠ and carcinoma,P<0.05. The difference of E-cad expression in histological classification of invasive carcinoma was as statistically significant as that in depth of muscular invasion,P<0.05.The difference of β-cat expression between normal cervical epithelia and CINⅡ-Ⅲ was as statistically significant as that between normal cervical epithelia and invasive squamous cell carcinoma,CINⅠ and carcinoma,P<0.05.The differences of β-cat expression in histological classifications of invasive carcinoma were statistically significant,P<0.05. The expression patterns between E-cad and β-cat in invasive carcinoma were correlated with each other, P<0.05.CONCLUSIONS:The abnormal expressions of E-cad and β-cat are early events in the progress of carcinoma.In cervical squamous cell carcinoma,their abnormal expressions may be related to the invasion of carcinoma.

关 键 词：钙结合蛋白质类/生物合成 钙粘着糖蛋白类/生物合成 宫颈上皮内瘤样病变/代谢 宫颈肿瘤/代谢 

分 类 号：R737.33[医药卫生—肿瘤]