阿伐他汀对实验性变态反应性脑脊髓炎治疗作用的初步研究  

Suppression of active experimental autoimmune encephalomyelitis in Lewis rats by using atorvastatin,an inhibitor of HMG-CoA reductase

作　　者：沈霞[1] 张作慧[1] 崔桂云[1] 雒东江[1] 王慧[2] 

机构地区：[1]徐州医学院附属医院神经内科,江苏徐州221002 [2]徐州医学院免疫学教研室,江苏徐州221002

出　　处：《徐州医学院学报》2005年第1期32-35,共4页Acta Academiae Medicinae Xuzhou

基　　金：徐州医学院附属医院课题(2003002)

摘　　要：目的观察阿伐他汀对实验性变态反应性脑脊髓炎(EAE)的治疗效果,初步探讨其治疗机制。方法采用Lewis大鼠建立EAE模型,口服给药,观察临床症状,MTT法检测T淋巴细胞增殖,ELISA法测淋巴细胞培养上清液中γ-干扰素(IFN-γ)的水平。结果阿伐他汀能显著改善EAE临床症状(P<0.05),同时明显抑制T淋巴细胞增殖(P<0.01),显著降低大鼠血清IFN-γ水平(P<0.05)。结论阿伐他汀通过抑制T淋巴细胞的增殖和减少炎性细胞因子的分泌,从而抑制髓鞘破坏,有效缓解EAE。Objective To investigate the effects of atorvastatin,a new synthetic inhibitor of HMG-CoA reductase,on experimental autoimmune encephalomyelitis (EAE) and the underlying mechanism of immunoregulation.?Methods EAE was induced in Lewis rats by immunization with guinea pig myelin basic protein.After oral administration of atorvastatin,the rats were examined for the development of neurological signs,T cell proliferative response and interferon-γ concentrations in the supernatant of splenocyte culture.?Results The clinical signs were suppressed significantly in atorvastatin group (P<0.05).T cell proliferation was significantly inhibited (P<0.01) and the interferon-γ concentration was significantly decreased (P<0.05).?Conclusions Atorvastatin can inhibit the proliferation of T cells and decrease the expression of proinflammatory cytokines,so to effectively ameliorate EAE in rats.

关 键 词：阿伐他汀 EAE 实验性变态反应性脑脊髓炎 T淋巴细胞增殖 治疗作用 IFN-Γ 大鼠 水平 结论 初步研究 

分 类 号：R744[医药卫生—神经病学与精神病学] R972.6[医药卫生—临床医学]