大黄、地塞米松对应激性溃疡的影响  

The effects of rhubarb and dexamethasome on stress ulcer

作　　者：程三放[1] 杜立峰[1] 朱新业[1] 杨杰[1] 刘红梅[1] 

机构地区：[1]西安交通大学第二医院急诊科,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2004年第6期603-604,607,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省科技攻关项目 (No .2 0 0 3K1 0 G1 2 2)

摘　　要：目的　研究大黄联用地塞米松对大鼠应激性溃疡的预防作用。方法　SD大鼠 80只 ,采用冷拘束制成应激性溃疡动物模型之后 ,随机分为 4组 :对照组、地塞米松干预组、大黄干预组、大黄联用地塞米松干预组 ,每组 2 0只 ,分别观察胃肠应激性溃疡的发生情况。结果　地塞米松干预组应激性溃疡发生率与正常组相同 ,大黄联用地塞米松组应激性溃疡发生率最低。结论　地塞米松并不增加应激性溃疡的发生率 。Objective To study the preventive effects of rh ub arb and dexamethasone(DXM) on stress ulcer. Methods A total of 80 healthy SD rats were made into stress ulcer animal model with tend cold. They were randomly assigned into four groups, including normal control group(20) , DXM intervention group(20), rhubarb intervention group(20) and rhubarb & DXM i ntervention group(20).All of them were observed for the incidence of stress ulce r. Results The stress ulcer incidence were the same in DXM stress ulcer group and normal control group. The stress ulcer incidence in rhuba rb and DXM group was the lowest. Conclusion The DXM doesn't increase the incidence of stress ulcer, while the rhubarb with DXM does decreas e the incidence of stress ulcer.

关 键 词：大黄 地塞米松 应激性溃疡 

分 类 号：R573.1[医药卫生—消化系统]