VAD方案治疗难治性晚期多发性骨髓瘤13例报告  

TREATMENT FOR REFRACTORY LATE MULTIPLES MYELOMA WITH VAD REGIMEN-A REPORT OF 13 CASES

作　　者：刘本俶[1] 段涓 章卫平[1] 杨健民[1] 

机构地区：[1]第二军医大学附属长海医院

出　　处：《上海医学》1993年第8期454-457,共4页Shanghai Medical Journal

摘　　要：1988年10月至1990年11月应用每天静滴 VCR 0.5～1.0mg,ADM10～20mg 和 DXM20mg。连续4天为1疗程的 VAD 方案治疗难治性晚期多发性骨髓瘤(MM)13例。每疗程后休息7～21天,重复治疗至取得缓解为止。连续观察治疗13例结果获显著效果者11例(84.6%),有效2例(15.4%),总有效率100%。取得缓解的疗程为2～6(平均3.6)疗程。该方案疗效出现快,对不适宜用烷化剂治疗的伴有骨髓瘤性肾病、高氮质血症和高钙血症者适用。着重讨论了在应用该方案治程中血像变化的规律及其对指导临床治疗的意义。From October 1988 through November 1990,13 cases of refractory late multiplemyeloma were treated with VAD regimen(VCR 0.5～1.0mg,ADM 10～20mg, DXM20mg).Daily intravenous drip for 4 days makes a course.Repeated courses was given,with an interval of 7～21 days between two courses,until the patients achieved remis-sion.The therapeutic effectiveness was apparent in 11(84.6%) cases and significant in2(15.4%)cases.The total effective rate was 100%.In general,the patients achievedremission after 2～6 courses((?)=3.6)of treatment.The VAD regimen is suitable forthe treatment of patients with multiple myelomatic nephrosis,hyperuremia or hypercal-cemia while these patients were unsuitable to be treated with alkylatirg agents.Thechanging pattern of hemogram during treatment and its significance of guiding clinicalmanagement were discussed.

关 键 词：骨髓瘤 药物疗法 VAD方案 联合用药 

分 类 号：R733.305[医药卫生—肿瘤]