急性淋巴细胞性白血病的细胞遗传学研究  

CYTOGENETIC STUDY ON ACUTE LYMPHOBLASTIC LEUKEMIA

作　　者：陈赛娟[1] 黄薇[1] 张影梅[1] 顾龙君[2] 钱珠兹[3] 谢文洁[2] 曹琪[2] 陈瑛[4] 王振义[4] 陈竺[4] 

机构地区：[1]上海第二医科大学瑞金医院 [2]上海第二医科大学新华医院 [3]上海市儿童医院 [4]上海第二医科大学血液研究所

出　　处：《上海医学》1993年第9期497-500,共4页Shanghai Medical Journal

基　　金：国家自然科学基金;卫生部青年基金

摘　　要：本文对40例中国人急性淋巴细胞白血病(急淋)进行了细胞遗传学的研究,发现正常核型为40%,染色体数量异常占42.5%,染色体结构异常为17.5%,特异染色体的异常包括有 t(9;22)(q34;q11),t(4;11)(q21,q23)和 t(8;14)(q24;q32)及环状染色体等。对2例急淋患者分析了疾病初发和复发时核型的变化,显示复发时有附加异常。研究认为细胞形态学,免疫表型和细胞遗传学的联合分析(MIC)有助于急淋的诊断和分型。此外,细胞遗传学检查对于急淋白血病的预后具有重要意义。Cytogenetic study was performed in 40 cases of chinese acute lymphoblastic leuke-mia(ALL).Normal karyotypes were found in 16 cases(40%),quantitative chromo-somal abnormalities in 17 cases (42.5%) and structural aberrations in 7 cases (17.5%).Among specific chromosomal anormalies were found the translocation t(9;22)(q34;qll),(t4;11)(q21;23),t(8;14)(q2432)and ring chromosome.Karyotype analysis was carriedout at the initial presentation of the disease and at relapse in two ca es,with addi-tional chromosomal abnormaliti(?)s being found at relapse.It was shown that the com-bined morphologic,immunologic and cytogenetic study (MIC) is valuable for the precisediagnosis and classification of ALL.Cytogenetic study also provides informationsindependent from other biological parameters for the prognosis of ALL.

关 键 词：白血病 细胞遗传学 免疫表型 

分 类 号：R733.703[医药卫生—肿瘤]