Animal model of high cholesterol atherosclerotic erectile dysfunction and mechanism of atherosclerotic erectile dysfunction  

作　　者：Guo-ShengYang Zhao-DianChen Hong-JuWang 

机构地区：[1]DepartmentofUrology [2]DepartmentofCardiovasology,FirstAffiliatedHospital,ZhejiangUniversityMedicalCollege,Hangzhou310003,China

出　　处：《Asian Journal of Andrology》2004年第4期342-342,共1页亚洲男性学杂志（英文版）

摘　　要：Aim: To establish the animal model of atherosclerotic erectile dysfunction (ED) induced by high cholesterol diet and explore the mechanism of atherosclerotic ED. Methods: Thirty male rabbits were divided at random into two groups: the normal diet (ND) group (n=10) and the high cholesterol (HCH) group fed with 1.5 % cholesterol diet (n=20). Serum total cholesterol, plaque areas of the ascending aorta, the ratio of intima/media thickness and level of vascular cell adhesion molecule 1 (VCAM 1) and the mRNA expression of internal pudendal artery were determined after twelve weeks. Results: After twelve weeks, all rabbits of the HCH group got hyperlipemia and 9 presented typical atherosclerosis (ATH). The rate of atherosclerosis induced by high cholesterol diet was 52.9 %. The serum total cholesterol levels of the ATH and HCH groups were higher than that of the ND group (P<0.01). The penile erection times and rate in the ATH and HCH groups were decreased significantly compared with the ND group (P<0.01). Both the ratio of intima/media thickness and the level of VCAM1 mRNA expression of internal pudendal artery in the ATH group were higher than those in the HCH and ND groups (P<0.01). Conclusion: It is easy, practicable and reliable to establish the animal model of atherosclerotic ED induced by high cholesterol diet. One of the main causes of atherosclerotic erectile dysfunction is hypercholesterolemia, which through VCAM1 may induce structural and functional modifications of the endothelium of the internal pudendal artery and make the corpus cavernosum ischemic.Aim: To establish the animal model of atherosclerotic erectile dysfunction (ED) induced by high cholesterol diet and explore the mechanism of atherosclerotic ED. Methods: Thirty male rabbits were divided at random into two groups: the normal diet (ND) group (n=10) and the high cholesterol (HCH) group fed with 1.5 % cholesterol diet (n=20). Serum total cholesterol, plaque areas of the ascending aorta, the ratio of intima/media thickness and level of vascular cell adhesion molecule 1 (VCAM 1) and the mRNA expression of internal pudendal artery were determined after twelve weeks. Results: After twelve weeks, all rabbits of the HCH group got hyperlipemia and 9 presented typical atherosclerosis (ATH). The rate of atherosclerosis induced by high cholesterol diet was 52.9 %. The serum total cholesterol levels of the ATH and HCH groups were higher than that of the ND group (P<0.01). The penile erection times and rate in the ATH and HCH groups were decreased significantly compared with the ND group (P<0.01). Both the ratio of intima/media thickness and the level of VCAM1 mRNA expression of internal pudendal artery in the ATH group were higher than those in the HCH and ND groups (P<0.01). Conclusion: It is easy, practicable and reliable to establish the animal model of atherosclerotic ED induced by high cholesterol diet. One of the main causes of atherosclerotic erectile dysfunction is hypercholesterolemia, which through VCAM1 may induce structural and functional modifications of the endothelium of the internal pudendal artery and make the corpus cavernosum ischemic.

关 键 词：ATHEROSCLEROSIS erectile dysfunction ANIMAL cell adhesion molecule 

分 类 号：R698[医药卫生—泌尿科学] R541.4[医药卫生—外科学]