铝碳酸镁联合吗丁啉治疗胆汁反流性胃炎的疗效观察  

Effect of hydrotalcid combined with domperidone on bile reflux gastritis

作　　者：唐世孝[1] 李小云[1] 唐川康[1] 邹义君[1] 

机构地区：[1]四川省泸州医学院附属医院消化科,泸州646000

出　　处：《重庆医学》2004年第12期1810-1811,共2页Chongqing medicine

摘　　要：目的　探讨铝碳酸镁和吗丁啉对胆汁反流性胃炎的疗效。方法　经胃镜及病理证实的胆汁反流性胃炎 94例 ,并随机分为 3组。Ⅰ组 :口服铝碳酸镁片每次 1.0 g ,每日 3次 ;Ⅱ组 :口服吗丁啉每次 10mg ,每日 3次 ;Ⅲ组 :同时口服铝碳酸镁片和吗丁啉。治疗 4周后观察上腹痛、腹胀、恶心、呕吐等症状积分的变化 ,并复查胃镜以评估病变的好转情况。结果　治疗后 3组患者症状的积分均明显减轻 (P <0 .0 5 ) ,总有效率分别为 93.5 %、80 %、10 0 % ,且Ⅲ组明显高于Ⅱ组 (P <0 .0 5 ) ;胃镜下病变好转的总有效率分别为 87%、73.3%、10 0 % ,且Ⅲ组也明显高于Ⅱ组 (P <0 .0 5 )。结论　铝碳酸镁可结合胃内胆汁 ,与促动力药吗丁啉合用 ,有效缓解胆汁反流性胃炎症状 ,为治疗胆汁反流性胃炎的有效方案。Objective To evaluate the effect of hydrotalcid combined with domperidone on bile reflux gastritis.Methods Ninety-four patients with bile reflux gastritis proven by gastroscopy and pathology were randomized into 3 groups: there were 31 patients in group Ⅰ which were treated with hydrotalcid 1.0g three times a day; 30 patients in group II which were treated with domperidone 10mg three times a day; 33 patients in group Ⅲ which were treated with hydrotalcid 1.0g three times a day combined with domperidone 10mg three times a day. The severity of the symptoms including abdominal pain, abdominal distention,nausea and vomiting were investigated before and four weeks after treatment.Gastroscopy was also reexamined. Results The severity of all the symptoms in the three groups decreased greatly after treatment(P<0.05)and the total effective rates were 93.5%,80%,100% respectively, group Ⅲ was higher than group Ⅱ (P<0.05). The total effective rates gastroscopically were 87%,73.3%,100% respectively, group Ⅲ was also higher than group Ⅱ (P<0.05). Conclusion Hydrotalcid combined with prokinetics domperidone is an effective treatment method for bile reflux gastritis because its binding with intragastric bile.

关 键 词：胆汁反流 胃炎 铝碳酸镁 吗丁啉 

分 类 号：R573.3[医药卫生—消化系统]