不同剂量干扰素治疗慢性乙型肝炎近期疗效观察  

Observation on Short-term Therapeutic Effect of Various Dosage of Interferon on Chronic Hepatitis B

作　　者：刘新枝[1] 于水玲[1] 

机构地区：[1]解放军第148医院,山东淄博255300

出　　处：《临床军医杂志》2004年第6期46-47,共2页Clinical Journal of Medical Officers

摘　　要：目的　观察不同剂量干扰素对慢性乙型肝炎的近期疗效。方法　将我院 1999年 12月— 2 0 0 3年 12月收治的 67例慢性乙型肝炎随机分为治疗组 (干扰素 5 0 0万U组 ) 3 4例和对照组 (干扰素 3 0 0万U组 ) 3 3例 ,两组均给予口服肌苷、维生素及静滴甘利欣治疗 ,在此基础上治疗组给予干扰素 5 0 0万U肌注 1次 /d ,2周后改为 3次 /周 ,总疗程 2 4周 ,对照组给予干扰素 3 0 0万U ,用法与疗程同治疗组。结果　疗程结束后治疗组与对照组ALT复常率分别为 88 2 % ,84.8% (P >0 0 5 ) ;治疗组与对照组HBeAg/抗 HBe血清转化率和HBV DNA近期阴转率分别为 5 8.88% ,2 7 3 %和 76.5 % ,45 5 % ,两者比较 (P <0 0 5 ) ;不良反应率两组相似 (P >0 0 5 )。结论　干扰素治疗慢性乙型肝炎在一定范围内 ,其近期疗效随着剂量增加而增加。Objective To observe the short-term therapeutic effect of various dosage of interferon on chronic hepatitis B.Methods Sixty-seven patients with chronic hepatitis B, admitted to our hospital from Dec.1999 to Dec. 2003, were divided into observing group (34) and control group (33) which were respectively administered with 5,000,000U and 3,000,000U of interferon, in addition to inosine, vitamins and diammonium glycyrrhizinate. The interferon was intramuscularly injected once a day for two weeks, and then three times a week for the other weeks. The total course was 24 weeks. Results There were respectively 88.2% and 84.8% of the patients in the two groups whose alanine transaminase (ALT) became normal after treatment, which showed no difference (P>0.05). The converting rates of serum HBeAg/anti-HBe respectively were 58.8% and 27.3%, and the short-term HBV DNA negative-converting rates were 76.5% and 45.5% respectively in observing group and in control group. Significant differences existed (P<0.05). There was no difference in side effect between the two groups. Conclusion The short-term effect of interferon on chronic hepatitis B turns ideal with the increase of the dosage to some extent.

关 键 词：慢性乙型肝炎 干扰素 大剂量 

分 类 号：R575.1[医药卫生—消化系统] R97[医药卫生—内科学]