注意缺陷多动障碍的遗传方式研究  

Study on Genetic Model of Attention Deficit Hyperactivity Disorder

作　　者：高雪屏[1] 杜亚松[2] 李雪荣[1] 苏林雁[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,长沙410011 [2]上海市精神卫生中心,上海203000

出　　处：《实用儿科临床杂志》2005年第1期55-57,共3页Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金资助 (39770 2 77)

摘　　要：目的　探讨注意缺陷多动障碍 (ADHD)可能的遗传方式。方法　用分离分析和多基因阈值模型理论方法估计 54个ADHD家系各级亲属遗传度和ADHD再病风险。结果　 1 .ADHD的平均遗传度为 (1 0 2 .47± 9.78) % ;2 .一级亲属患病风险增高 (2 3 .0 % )明显高于群体患病率 (2 .6 % ) ,各级亲属患病率随着与先证者的亲属关系级数递增而剧减。结论　ADHD的遗传方式可能是具有主基因的多基因遗传。其遗传因素在决定疾病易患性变异上可能有重要作用 ,除微效、累加的多对基因外 ,可能还存在主基因效应。Objective To analyze the genetic model of attention deficit hyperactivity disorder(ADHD).Methods The segregation analysis and polygenic multiple threshold model were used to prove the polygenic model and to estimate the heritability and recurrence risk of ADHD in each degree relatives.Results 1. The average heritability of ADHD was (102.47±9.78)%;2.The first-degree relatives of probands were in high risk for ADHD(23.0%)compared with colony prevalence rate(2.6%). The ADHD prevalence of each degree relatives rapidly decreased with the increased magnitude of consanguineous relationship of each degree relatives and ADHD probands. Conclusions The genetic model of ADHD is the most likely polygenic inheritance with major genes, which suggested that the genetic factor might play an important role in the liability variance of ADHD.Apart from the involvement of multiple genes,each gene contributes a small additive effect,and the major genes may be involved as well.

关 键 词：注意缺陷多动障碍 分离分析 多基因阈值模型理论 

分 类 号：R749.94[医药卫生—神经病学与精神病学]