牛磺酸对染铅大鼠海马神经元型一氧化氮合酶阳性神经元的影响  

THE EFFECT OF TAURINE ON nNOS POSITIVE NEURON IN HIPPOCAMPUS OF RAT INDUCED BY LEAD LESION

作　　者：杨烽[1] 李积胜[1] 刘亚华[1] 王大宁[1] 

机构地区：[1]武警医学院军事预防医学研究所,天津300162

出　　处：《营养学报》2004年第6期430-433,共4页Acta Nutrimenta Sinica

基　　金：国家自然科学基金(No.39870689)

摘　　要：目的:探讨牛磺酸拮抗铅损害学习记忆能力的作用。方法:采用ABC免疫组织化学方法,研究饮用含不同剂量醋酸铅(0.02、0.2g/L)饮水和含不同剂量牛磺酸(5、10g/kg)饲料喂养的大鼠海马神经元型一氧化氮合酶(nNOS)阳性神经元数量的变化。结果:牛磺酸能明显增加染铅大鼠海马nNOS阳性神经元的数量。结论:牛磺酸对铅损害学习记忆能力有较明显的拮抗作用。Objective: To study the effect of taurine to resist the impact of lead on learning and memory. Methods: ABC immunohistochemistry method was used to study the quantity change of nNOS positive neuron in hippocampus of the rats which were fed with distinct dosage of lead acetate in drinking water (0.02, 0.2 g/L) and distinct dosage of taurine (5,10 g/kg) in feed. Rusults: Taurine could increase nNOS positive neuron quantity obviously in hippocampus of rats induced by lead lesion. Conclusion: Taurine could resist impact of lead on learning and memory obviously.

关 键 词：牛磺酸 铅 海马 神经元型一氧化氮合酶 学习记忆 

分 类 号：R114[医药卫生—卫生毒理学]