血清可溶性尿激酶受体、胸腺肽α_1水平和血管性血友病因子裂解酶活性在肿瘤患者预后中的意义  

Prognostic significance of serum soluble urokinase receptor, thymosin alpha 1 levels and von Willeband factor-cleaving protease activity in cancer patients

作　　者：高维强[1] 王兆钺[1] 苏健[1] 白霞[1] 阮长耿[1] 

机构地区：[1]苏州大学附属第一医院江苏省血液研究所,苏州215006

出　　处：《临床内科杂志》2005年第1期22-24,共3页Journal of Clinical Internal Medicine

摘　　要：目的　了解恶性肿瘤患者血清可溶性尿激酶受体 (suPAR)、胸腺肽α1(Tα1)水平和血管性血友病因子裂解酶 (vWF cp)活性水平与患者预后的关系并作比较。方法　以免疫放射分析、酶联免疫吸附试验和残余胶原结合力 (R CBA)的方法分别检测 60例手术前恶性肿瘤患者血清su PAR、Tα1水平和vWF cp活性并随访了 5 1例患者的预后情况。应用Kaplan Meier生存分析了解上述三个指标对恶性肿瘤患者的预后价值并比较之。其临界点选择健康对照数值的均数加 2倍标准差。结果　上述三个指标在术前恶性肿瘤患者中均显著改变 ,但仅suPAR水平和vWF cp活性水平与患者的预后相关。进一步以多元回归分析三个指标对患者预后的影响发现 ,以suPAR的影响最为显著。结论　suPAR可作为恶性肿瘤患者预后判断的可靠指标。Objective To investigate and compare the prognostic impact of serum solube urokinase receptor (suPAR),thymosin alpha 1 (Tα 1) levels and von Willebrand factor-cleaving protease (vWF-cp) activity in cancer patients.Methods The serum suPAR,Tα 1 levels and vWF-cp activities in 60 cancer patients were measured by immunoradiometric assay,enzyme-linked immunoadsordent assay and residual collagen binding activity(R-CBA),respectively.The prongostic significance of the three molecules in 51 cancer patients was analyzed using Kaplan-Meier survival analysis and Cox’s proportional hazards analysis.Results Although the suPAR,Tα 1 levels and vWF-cp activities significantly altered in cancer patients,only the suPAR level and vWF-cp activities were shown to be related with prognosis.Moreover,Cox’s analysis data showed that the suPAR level was still prongostic significance in multivariate analysis.Conclusion Serum suPAR level is a valuable index in prediction of the prognosis of preoperative cancer patients.

关 键 词：尿激酶受体 胸腺素Α1 血管性血友病因子 裂解酶 肿瘤 预后 

分 类 号：R730.7[医药卫生—肿瘤]