N-烷基-4-哌啶酮类化合物的合成  

Syntheses of N-Alkyl-4-piperidinones

作　　者：韩娟[1] 李乐平[1] 段学民[1] 陈立功[1] 

机构地区：[1]天津大学药物科学与技术学院,天津300072

出　　处：《精细化工》2005年第1期71-73,共3页Fine Chemicals

摘　　要：对N 烷基 4 哌啶酮类化合物的合成进行了研究,重点对其中的正丁基、正己基、正辛基、苄基取代物进行了合成。以胺类化合物为原料,与丙烯酸甲酯经过两次Michael加成得到N,N 二丙酸甲酯类化合物,该化合物在甲醇钠存在下进行环合,在酸性条件下脱羧,高收率得到4 哌啶酮类化合物,从而证明了这是一条合成N 取代 4 哌啶酮类化合物的普遍方法。The syntheses of N-alkyl-4-piperidinones were studied.The syntheses of butyl,hexyl,octyl and benzyl substituted piperidinones were emphatically examined.The target compounds were obtained in high yield through Michael conjugative addition of amines to methyl acrylates,cyclocondensation of the obtained diadducts in the presence of sodium methoxide,and decarboxylation of the cyclocondensation products in acid.These results indicated that this method affords a general way to synthesize N-subtitued-4-piperidinones.

关 键 词：哌啶酮 迈克尔加成 环合 脱羧 

分 类 号：TQ460.31[化学工程—制药化工]