音乐对大鼠学习和记忆以及海马NMDA受体表达的影响  

Effect of music on learning and memory and expression of NMDA receptor in hippocampus of rat

作　　者：王增贤[1] 王晓亚[1] 王怀经[2] 李振中[2] 王越[2] 邢子英[2] 

机构地区：[1]泰山医学院基础医学研究所,山东泰安271000 [2]山东大学医学院解剖学教研室,山东济南250012

出　　处：《第四军医大学学报》2004年第24期2237-2240,共4页Journal of the Fourth Military Medical University

摘　　要：目的 :研究音乐对大鼠空间学习和记忆及海马内NMDA受体表达的影响 .方法 :用Morris水迷宫行为检测法 ,检测音乐刺激后大鼠学习和记忆能力的变化 ;免疫组化和PCR技术 ,检测海马NMDA受体及编码NMDA受体mRNA的表达 .结果 :音乐刺激后 ,大鼠信息游泳和选择游泳的逃避潜伏期缩短 ,选择游泳选择正确率提高 ,其变化以持续音乐刺激组最明显 ,生后音乐组次之 ,对照组最小 ;音乐刺激后海马神经元NMDA受体及其mRNA表达增加 .结论 :音乐刺激能提高大鼠空间记忆能力 ,增强海马神经元NMDA受体及编码NMDA受体的mRNA表达 .AIM: To study the effect of music on the spatial learning and memory and the expression of NMDA receptor in hippocampus of rats. METHODS: The non-matched position task in the Morris' water maze was used to examine the behavior changes of learning and memory, and immunohistochemistry and PCR techniques were employed to measure the expression of NMDA receptor and its mRNA in hippocampus in Wistar rats after music stimulation. RESULTS: After music exposure, the spatial memory of rat improved, the avoiding latency of information swim and choice swim shortened, and the choice accuracy in choice swim increased. The strongest effect of music was demonstrated in persistent music exposure group, moderate in the postnatal music exposure group, and the least in control groups. The expression of NMDA receptor and its mRNA in hippocampus strengthened. CONCLUSION: Music can improve the spatial memory of rats and increase the expression of NMDA receptor and its mRNA in hippocampus.

关 键 词：学习 记忆 受体 N-甲基-D-天冬氨酸 音乐 大鼠 

分 类 号：Q426[生物学—神经生物学]