滤泡上皮源性甲状腺癌的性类固醇激素受体的临床病理研究  被引量:1

Expression of sex steroid hormone receptors (SSHR) in thyroid carcinoma

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作  者:王翠芳[1] 李冠群[1] 姜卫国 

机构地区:[1]中国医科大学第二临床学院病理科,110000

出  处:《实用肿瘤杂志》1993年第3期145-147,共3页Journal of Practical Oncology

摘  要:应用ABC免疫组化法于石蜡切片检测70例甲状腺癌三种性类固醇激素受体(SSHR)的表达。结果表明:雌激素、孕激素和雄激素三种受体在不同的组织类型表达率不同,以甲状腺乳头状腺癌阳性率最高,并见于转移的淋巴结,滤泡状腺癌的阳性率次之,未分化癌三种受体的表达均阴性。提示肿瘤细胞分化程度的越差,SSHR的表达越弱。并且三种受体的表达具有相关一致性。淋巴结的转移状态与SSHR的表达对预后的判断无相关性。32例随访病例表明:5年内无癌复发者SSHR阳性率高于有癌复发者。预后指数的高低同SSHR阳性率的表达呈正相关。Paraffin-embedded sections from 70 patients with thyroid carcinoma were assayed for the expression of estrogen receptor (ER), progesterone receptor (PR) and androgen receptor (AR) by the avidin-biotin complex method. Results showed a significantly positive correlationship between the three SSHRs and three different kinds of thyroid carcinoma. Papillary thyroid carcinoma had a higher expression of receptors than had the other kinds of thyroid carcinoma. The positive rates of ER, PR and AR were 75.0%(39/52), 65.4%(34/52) and 67.3%(35/52) res- pectively in papillary carcinoma and 35.7%(5/14), 42.9%(6/14) and 21.4% (3/14) in follicular carcinoma. But the ER、PR and AR were totally negative in the undifferentiated carcinoma, The free-recurrence cases in five years had higher SSHR than the recurrence cases. It is thus indicated that the ER、PR and AR detected by the ABC method might serve as biomarkers for the evaluation of tumor differentiation and prognostic indicators in thyroid cancinoma.

关 键 词: 性类固醇激素 受体 甲状腺肿瘤 

分 类 号:R736.103[医药卫生—肿瘤]

 

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