膀胱移行细胞癌的分期分级及复发与PTEN和粘着斑激酶的表达  

The corelation between tumor stage and grade and postoperative reccurrence rate of transitional cell carcinoma of bladder and the expressions of PTEN and FAK

作　　者：张宇曦[1] 宋永胜[2] 黄晓明[1] 安康[1] 刘树民[1] 张崇伦[1] 刘鹏[1] 王雪松[1] 崔军[2] 

机构地区：[1]辽宁省人民医院泌尿外科,沈阳110015 [2]中国医科大学附属第二医院泌尿外科

出　　处：《临床泌尿外科杂志》2005年第2期95-97,共3页Journal of Clinical Urology

摘　　要：目的:探讨在10号染色体上磷酸酶和张力蛋白同系化合物缺失(PTEN) 和粘着斑激酶(FAK)在膀胱移行细胞癌中表达的意义。方法:应用 SP免疫组织化学染色法检测 96 例膀胱移行细胞癌中 PTEN和 FAK的表达。结果:PTEN和 FAK表达的阳性率在 Ta^1 中分别为71.43%(30/42)和47.62%(20/42), T2~4 分别为37.04%(20/54)和85.19% (46/54) (P < 0.05), G1~2 分别为48.65% (36/74)和68.92% (51/74), G3~4 分别为63.64%(14/22) 和68.18%(15/22)(P>0.05),在初发肿瘤中分别为58.67%(44/75)和62.67%(47/75),复发肿瘤中分别为28.57%(6/21)和90.48%(19/21)(P<0.05)。PTEN阳性表达中 FAK 阳性表达52.00% (26/50), PTEN阴性表达中FAK阳性表达86.96%(40/46)(P<0.05)。结论:PTEN和FAK的阳性表达与膀胱移行细胞癌的分期有关,与分级无关,PTEN可下调 FAK的表达,在复发肿瘤中 PTEN表达下调,FAK表达则增高。Objective:To study the expressions of PTEN AND FAK and their clinical significance in patients with transitional cell cancer of bladder. Methods:The expressions of PTEN and FAK in 96 cases of bladder cancer (TCC) were detected by strepravidin-peroxidase immunohistochemical method. Results:The positive expression rates of PTEN in different group were as follows:T a-1 71.43%(30/42), T 2-4 37.04%(20/54)(P< 0.05); G 1-2 48.65%(36/74), G 3-4 63.64%(14/22)(P> 0.05),primary cancer 58.67%(44/75), reccurrent cancer 28.57%(6/21)(P<0.05)。The positive expression rates of FAK were as follows: T a-1 47.62%(20/42), T 2-4 85.19%(46/54),P< 0.05; G 1-2 68.92%(51/74),G 3-4 68.18%(15/22),P> 0.05, primary cancer 62.67%(47/75), reccurrent cancer 90.48%(19/21)(P< 0.05); PTEN(+) 52.00%(26/50),PTEN(-) 86.96%(40/46)(P< 0.05). Conclusions:The positive expressions of PTEN and FAK are significantly corelated to tumor stage and the postoperative reccurrence rate. PTEN can reduce the expression of FAK.

关 键 词：膀胱肿瘤 癌 移行细胞 10号染色体上磷酸酶和张力蛋白同系化合物缺失 粘着斑激酶 

分 类 号：R737.14[医药卫生—肿瘤]