妊娠期肝内胆汁淤积症患者瘦素水平检测的临床意义  

Clinical significance of serum leptin measurement in patient with intrahepatic cholestasis of pregnancy

作　　者：王彦德[1] 孙袁[1] 刘虹[1] 张志萍[1] 周红[1] 刘英[1] 

机构地区：[1]贵阳市妇幼保健院,贵州贵阳550003

出　　处：《检验医学》2005年第1期7-9,共3页Laboratory Medicine

摘　　要：目的　检测妊娠期肝内胆汁淤积症(ICP)患者产前及产后血清瘦素水平,以探讨瘦素与ICP的关系。 方法　采用放射免疫分析法(RIA)测定30例ICP患者和40名正常妊娠妇女产前及产后1周血清瘦素水平及 30名健康未孕妇女瘦素水平。结果　ICP组产前瘦素水平为(35.41±9.39)μg/L,明显高于正常妊娠组产前瘦 素水平[(21.30±5.18)μg/L],两组比较差异有显著性(P<0.01)。ICP组产后瘦素水平为(8.67±3.07)μg/L, 与正常妊娠组产后瘦素水平[(7.56±2.76)μg/L]比较差异无显著性(P>0.05),两组分别与健康未孕组瘦素 水平[(7.44±2.48)μg/L]比较差异均无显著性(P均>0.05)。结论　妊娠妇女瘦素水平的异常升高与ICP有 关,且与胎盘来源的瘦素有一定关系。Objective To investigate the relationship between leptin and intrahepatic cholestasis of pregnancy (ICP) by measuring the serum leptin before and after delivery. Methods The levels of serum leptin in 30 patients with ICP and 40 normal pregnant women were measured by RIA before and one week after delivery; Serum leptin of 30 normal non-pregrant women was also measured. Results The level of leptin in patients with ICP before delivery [(35.41±9.39) μg/L] was significantly higher than that of normal pregnant women [(21.30±5.18) μg/L](P<0.01). There was no significant difference between patients with ICP one week after delivery [(8.67±3.07) μg/L] and normal pregnant women [( 7.56±2.76) μg/L](P>0.05). Both showed no significant difference compared to normal non-pregnant women [(7.44±2.48) μg/L](P>0.05). Conclusions The abnormal increase of leptin levels in pregnant women may be relevant to ICP.

关 键 词：瘦素水平 患者 产后 妊娠期肝内胆汁淤积症 ICP 产前 血清瘦素 显著性 

分 类 号：R714[医药卫生—妇产科学] R544.1[医药卫生—临床医学]