丁丙诺啡脱毒过程催瘾反应相关因子的研究  

Related Factors of Buprenorphine's Antagonist-precipitated Withdrawal Response druing Detoxification

作　　者：蒋铁平[1] 刘永红[1] 王红[1] 陈辞珍[1] 彭银燕[1] 田纳[1] 吴少泉[1] 

机构地区：[1]湖南省脑科医院,长沙410007

出　　处：《中国药物滥用防治杂志》2004年第6期332-334,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:观察丁丙诺啡在脱毒过程中的催瘾反应及与其相关因子的关系。方法:在相同剂量的丁丙诺啡治疗条件下,前瞻性的观察治疗后的催瘾反应,并对催瘾组和非催瘾组进行相关因子值的比较。结果:丁丙诺啡(首日剂量2.7 mg)在脱毒过程中的催瘾发生率为28.37%,症状在使用药物后平均56.59分钟出现,催瘾症状严重程度分布:轻度6例,中度8例,重度7例。催瘾组与非催瘾组的相关因子值的比较显示:催瘾组体重显著轻于非催瘾组(P <0.05),催瘾组末次吸毒量明显高于非催瘾组(P <0.01),催瘾组所吸海洛因纯度较非催瘾组高(P <0.01),催瘾组与非催瘾组用药时间无显著性差异(P >0.05)。结论:丁丙诺啡在脱毒中出现的催瘾反应是脱毒开始阶段的主要障碍。吸毒者体重较轻,所吸毒品纯度较高,末次吸毒量较高者容易出现催瘾反应,催瘾发生与用药时间的先后无直接关联。Objective: To study buprenorphine's antagonist-precipitated withdrawal response (APWR) and its related factors in detoxification course. Methods: Using same dose of buprenorphine, then, observing APWR after treatment, and comparing related factors scores between APWR group and non-APWR group. Results: Buprenorphine's APWR incidence rate was 28.37%,the symptoms appeared 56.59 minutes in average after using drug. The distribution of APWR symptom severity was as follows : mild: 6 cases; moderate: 8 cases; serious: 7 cases. The data of comparison of related factors scores between APWR and non-APWR groups were as follows: the body weight of APWR group was lighter than that of non- APWR group (P < 0.05). The dose of heroin used at last time in APWR group was much higher than that of non-APWR group (P < 0.01). The pureness of heroin used in APWR group was better than that of non-APWR group too (P < 0.01). Conclusion: Buprenorphine's APWR is a main hedge in initial stage of detoxification.

关 键 词：丁丙诺啡 相关因子 吸毒 反应 观察 治疗后 轻度 过程 结论 前瞻性 

分 类 号：R749.61[医药卫生—神经病学与精神病学]