D-山梨醇肝清除率评估肝储备功能的临床研究  

Clinical study of evaluating hepatic functional reservation by a D-sorbitol hepatic clearance test.

作　　者：雷团结[1] 黎一鸣[2] 陈域[1] 任贵兵[2] 

机构地区：[1]解放军451医院普外科,西安710054 [2]西安交通大学第二医院普外科,西安710004

出　　处：《中国实用外科杂志》2005年第2期103-104,共2页Chinese Journal of Practical Surgery

摘　　要：目的探讨D山梨醇清除率在评估肝储备功能中的作用。方法2000年1月至2001年12月对50例行断流手术的肝硬化合并门静脉高压症病人术前进行肝功能分级及D山梨醇肝清除率测定,分析D山梨醇肝清除率与肝功能分级及断流术后并发症发生率的关系。结果ChildPugh肝功能分级为A级的病人比B级病人D山梨醇肝清除率高,断流术后无并发症病人比有并发症病人D山梨醇肝清除率高,在肝功能B级组中随着D山梨醇肝清除率降低,术后并发症发生率增高。结论D山梨醇肝清除率能够反映病肝储备功能,联合应用D山梨醇肝清除率和肝功能分级可以更客观地评估病肝储备功能。Objective To explore the effect of D-sorbitol hepatic clearance test in evaluating hepatic functional reservation parameters.Methods From January 2000 to December 2001,50 cirrhotic patients were performed D-sorbitol hepatic clearance test and Child classification preoperatively.The relations among D-sorbitol hepatic clearance,classification and complications were studied.Results The D-sorbitol hepatic clearance was higher in classification A patients than in classification B patients.The D-sorbitol hepatic clearance was higher in no-complications group than in complications group.In classification B patients,with the level of D-sorbitol hepatic clearance descending,complications incidence was increasing.Conclusion D-sorbitol hepatic clearance is correlated with hepatic functional reserve.Combining D-sorbitol hepatic clearance test and Child classification can evaluate hepatic functional reservation more objectively.

关 键 词：D-山梨醇 清除率 肝储备功能 肝功能分级 病人 断流术后 并发症 结论 合并 目的 

分 类 号：R575[医药卫生—消化系统] R657.34[医药卫生—内科学]