幼年性血管瘤中葡萄糖转运蛋白1及CD32的表达  

Expression of GLUT1 and CD32 in Juvenile Hemangioma

作　　者：孙志军[1] 夏风[2] 张露[3] 张文峰[1] 赵怡芳[1] 

机构地区：[1]武汉大学口腔医院口腔颌面外科,武汉430079 [2]武钢大冶铁矿职工医院,黄石435006 [3]武汉大学口腔医学院口腔生物医学工程教育部重点实验室,武汉430079

出　　处：《武汉大学学报（医学版）》2005年第1期48-49,57,F003,共4页Medical Journal of Wuhan University

基　　金：湖北省科技攻关计划资助项目 (编号 :2 0 0 1S45 3 2 )

摘　　要：目的 :研究幼年性血管瘤中葡萄糖转运蛋白 1(GLUT1)、CD32的表达及与其他血管肿瘤的差异。方法 :免疫组织化学SP法分别检测 2 6例幼年性血管瘤、2 8例化脓性肉芽肿、2 5例中间性血管内皮瘤、4例血管肉瘤、7例血管外皮瘤及 6例胎盘组织中GLUT1及CD32的表达。结果 :幼年性血管瘤及胎盘绒毛膜表达GLUT1及CD32 ,化脓性肉芽肿、中间性血管内皮瘤、血管肉瘤及血管外皮瘤GLUT1、CD32染色阴性。结论 :幼年性血管瘤与胎盘绒毛膜共同表达GLUT1及CD32 ,二者内皮的表型具有相似性 ,与其他血管肿瘤有所不同。Objective: To investigate the difference and significance of GLUT1 and CD32 (FCγRⅡ) expression in juvenile hemangioma, vascular tumors and placental chorionic villi. Methods: Immunoreactivities for GLUT1 and CD32 were assessed in 26 juvenile hemangiomas, 28 pyogenic granulomas, 25 intermediate hemangioendotheliomas, 4 angiosarcomas, 7 hemangiopericytomas and 6 placentas. Results: GLUT1 and CD32 immunoreactivities were observed in all specimens of juvenile hemangiomas and 6 placental chorionic villi. Reactivity for GLUT1 and CD32 was undetectible in any of other vascular tumors. Conclusion: Juvenile hemangiomas share the similar endothelial phenotype by co-expression GLUT1 and CD32 with placental chorionic villi, and so, it is different from other vascular tumors.

关 键 词：血管瘤 血管肿瘤 葡萄糖转运蛋白 CD32 

分 类 号：R732.2[医药卫生—肿瘤] R739.8[医药卫生—临床医学]