MDM_2及p53在口腔疣状癌中的表达研究  

The Expression Study of MDM_2 and p53 in Oral Verrucous Carcinoma

作　　者：唐瞻贵[1] 邹萍[2] 姚志刚[3] 蒋海鹰[4] 冯德云[4] 

机构地区：[1]中南大学湘雅医院口腔颌面外科,长沙410078 [2]深圳市中心医院口腔科,深圳518000 [3]中南大学湘雅医院口腔病理科,长沙410000 [4]中南大学湘雅医院 病理科,长沙410000

出　　处：《口腔颌面外科杂志》2004年第4期304-306,共3页Journal of Oral and Maxillofacial Surgery

基　　金：湖南省自然科学基金资助项目(01JJY2093).

摘　　要：目的:研究癌基因蛋白(MDM2)过度表达及p53功能失活与口腔疣状癌发生的相关性。方法:利用免疫组 织化学SP法检测13例口腔疣状癌、10例口腔高分化鳞癌、10例口腔低分化鳞癌组织中的MDM2蛋白及p53蛋白 表达,并分析其相关性。结果:口腔疣状癌中的MDM2蛋白表达与口腔鳞癌间差异无显著性,而其p53蛋白表达 明显低于口腔鳞癌(P<0.01);虽然两者之间无明显相关性(P>0.05),但在13例MDM 蛋白表达阳性的口腔疣 状癌中,仅4例(30.8％)呈现p53阳性,69.2％的病例呈现p53阴性表达。结论:MDM2蛋白过度表达与p53失活 并存可能与口腔疣状癌的发生相关。Objective: To study the relationship between MDM2 overexpression and p53 inactivation in oral verrucous carcinoma. Methods: Immunohistochemistry assay was performed in 13 cases of oral verricous carcinoma ( VC) and 20 cases of oral squamous epithelial cells carcinoma (SCC) using monoclonal antibody against MDM2 and p53 protein. Results: The MDM2 positive expression in VC were not significantly higher in SCC (P<0.01). The p53 positive expression in VC were significantly lower in SCC ( P < 0. 01). The expression of p53 and MDM2 were not significantly correlated ( P > 0. 05). But there were 30. 8% p53 positive expression and 69.2% p53 negative expression in the MDM2 positive expression cases. Conclusion; MDM2 overexpression and p53 inactivation play an important role in oral verrucous carcinoma. But there are no significant correlativity between MDM2 and p53 in oral verrucous carcinoma.

关 键 词：MDM2 P53 口腔疣状癌 口腔鳞癌 免疫组织化学 

分 类 号：R739.8[医药卫生—肿瘤]