涎腺粘液表皮样癌术后转移的临床与病理研究  

Study of the Correlative Clinicopathologic Factors Influencing the Postoperative Metastasis of Mucoepidermoid Carcinoma in Salivary Glands

作　　者：李春智[1] 孙沫逸 张晓晖[3] 王贺忠[1] 尉文华[1] 

机构地区：[1]解放军第251医院口腔颌面外科,张家口075000 [2]第四军医大口腔医学院,西安510032 [3]第四军大西京医院,西安510032

出　　处：《口腔颌面外科杂志》2004年第4期342-344,共3页Journal of Oral and Maxillofacial Surgery

摘　　要：目的:分析涎腺粘液表皮样癌患者术后发生转移的相关临床病理因素。方法:对第四军医大学口腔医学 院首次手术治疗5年以上以及不足5年而发生转移的59例涎腺粘液表皮样癌患者进行回顾性研究,对各项临床、 病理指标通过SPSS软件进行单因素及多因素回归分析。结果:本组涎腺粘液表皮样癌术后转移率为23.73％。 单因素分析发现术前是否出现症状、肿瘤大小、临床分期、骨有无侵犯及分化程度均与术后是否发生转移相关。多 因素分析表明,分化程度以及骨有无侵犯是影响涎腺粘液表皮样癌患者术后转移的主要因素。结论:涎腺粘液表 皮样癌分化程度、骨有无侵犯是影响患者术后转移的主要危险因素。Objective: To analysis the correlative clinicopathologic factors influencing the postoperative metastasis of mu-coepidermoid carcinoma in salivary glands. Methods: A restropective study was done. Fifty nine cases with mucoepider-moid carcinoma of salivary glands underwent surgical resection in College of Stomatology, FMMU, and they have been followed up for more than five years, or less than five years but the metastasis had been discovered. Statistical analysis was performed using a computer program (SPSS). The univariate and multivariate analyses were treated by logistic regression, respectively. Results: The metastatic rate was 23.73%. The univariate analysis indicates that postoperative metastasis associated with the presence of clinical symptoms (P=0.002) , the size of tumor (P=0.027) , clinical stage (P = 0.032), with or without bone involvment (P =0.006) and grades of differentiation (P =0.002). The multivariate analyses suggest that grades of differentiation and with or without bone involvment are the main factors influencing the postoperative metastasis. Conclusion: The grades of differentiation and with or without bone involvment are the risk factors that influencing the postoperative metastasis of mucoepidermoid carcinoma in salivary glands.

关 键 词：癌 粘液表皮样 涎腺肿瘤 转移 预后 

分 类 号：R739.8[医药卫生—肿瘤]