血清PSA结合病理分级预测前列腺癌骨转移  

Combination of Prostate Specific Antigen and Pathological Stage Regarding to Gleason Score to Predict Bone Metastasis of Newly Diagnosed Prostate Cancer

作　　者：王振[1] 周立权[1] 高江平[1] 史立新[1] 张晓毅[1] 洪宝发[1] 

机构地区：[1]中国人民解放军总医院泌尿外科,北京100853

出　　处：《标记免疫分析与临床》2004年第4期219-221,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨血清PSA结合前列腺癌病理分级预测前列腺癌骨转移价值。对 2 0 2例新诊断的前列腺癌患者 ,以同位素全身骨扫描为金标准分为骨转移和非骨转移组 ,分析血清PSA水平、病理分级和同位素骨扫描结果的关系。PSARIA检测结果 :血清PSA <10 μg/L和PSA <2 0 μg/L病理分级中、高度分化者骨转移的发生率为 7%和6 % ,两者无统计学差异 ;PSA <2 0 μg/L病理分级低度分化者和血清 2 0 μg/L <PSA <10 0 μg/L者 ,骨转移的发生率为 33%和 39% ,两组无统计学差异 ;PSA >10 0 μg/L者骨转移发生率为 80 %。建议排除对没有骨痛、血清PSA <10 μg/L和PSA <2 0 μg/L病理分级中、高度分化者和PSA >10 0 μg/L者行同位素骨扫描。To determine the value of tumor grade and serum prostate-specific antigen in predicting skeletal metastases in untreated prostate cancer, the results of bone scans were related retrospectively to levels of serum PSA and tumor Grade based on pathologyical examination in 202 patients with prostate cancer newly diagnosed.Skeletal metastases were present in 7% of patients with serum PSA<10μg/L and in 6% of those with serum PSA<20μg/L in grades 1 and 2, no statistically significant differences between the two groups; in 33% and 39% of patients with PSA<20μg/L in grades 3 and serum 20μg/L<PSA<100μg/L, no statistically significant differences were found in those; 80% of patiens with serum PSA>100μg/L.Bone scans are omitted likely in a man newly diagnosed with prostate cancer who has no suggestive clinical features, a serum PSA<20μg/L with well or moderately differentiated or serum PSA>0μg/L.

关 键 词：前列腺肿瘤 癌 骨转移 前列腺特异抗原 同位素骨扫描 

分 类 号：R737.25[医药卫生—肿瘤]